{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T06:19:04Z","timestamp":1789539544667,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,3,23]],"date-time":"2017-03-23T00:00:00Z","timestamp":1490227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ftirma Kurumu","doi-asserted-by":"publisher","award":["(TUBITAK\/SBAG 114S767)"],"award-info":[{"award-number":["(TUBITAK\/SBAG 114S767)"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ftirma Kurumu","doi-asserted-by":"publisher","award":["TUBITAK\/SBAG 114S767"],"award-info":[{"award-number":["TUBITAK\/SBAG 114S767"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of the present study was to compare the effectiveness of combined Er:<jats:styled-content style=\"fixed-case\">YAG<\/jats:styled-content> and Nd:<jats:styled-content style=\"fixed-case\">YAG<\/jats:styled-content> laser therapy to that of scaling and root planing with hand instruments in non\u2010surgical treatment of chronic periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Twenty\u2010five systemically healthy patients with chronic periodontitis were selected for this study. The quadrants were randomly allocated in a split\u2010mouth design to either combined Er:<jats:styled-content style=\"fixed-case\">YAG<\/jats:styled-content> (160\u00a0mJ\/pulse, 10\u00a0Hz) and Nd:<jats:styled-content style=\"fixed-case\">YAG<\/jats:styled-content> laser (100\u00a0<jats:styled-content style=\"fixed-case\">mJ<\/jats:styled-content>\/pulse, 20\u00a0Hz) therapy (test group) or <jats:styled-content style=\"fixed-case\">scaling and root planing<\/jats:styled-content> alone (control group). At baseline, 1\u00a0month and 3\u00a0months after treatment, plaque index, gingival index, probing depth, clinical attachment level and bleeding on probing (%), were recorded and gingival crevicular fluid and subgingival plaque samples were taken. The gingival crevicular fluid levels of interleukin\u20101\u03b2 and tumor necrosis factor\u2010\u03b1 were analyzed by <jats:styled-content style=\"fixed-case\">enzyme\u2010linked immunosorbent assay<\/jats:styled-content>. Quantitative analysis of red complex bacteria was performed using quantitative real\u2010time polymerase chain reaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The clinical parameters had significantly improved for both groups after treatment. There were statistically significant differences in <jats:styled-content style=\"fixed-case\">probing depth<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">clinical attachment level<\/jats:styled-content> between the test and control groups only for deep pockets (\u22657\u00a0mm) (<jats:italic>P<\/jats:italic>&lt;.05). No significant differences between the two groups were observed for the biochemical and microbiological parameters at any time points (<jats:italic>P<\/jats:italic>&gt;.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present study suggests that a combined course of Er:<jats:styled-content style=\"fixed-case\">YAG<\/jats:styled-content> and Nd:<jats:styled-content style=\"fixed-case\">YAG<\/jats:styled-content> laser therapy may be beneficial particularly in inaccessible areas such as deep pockets on a short\u2010term basis. Further, well\u2010designed studies are required to assess the effectiveness of the combination of these lasers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12454","type":"journal-article","created":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T05:14:58Z","timestamp":1490332498000},"page":"853-862","source":"Crossref","is-referenced-by-count":41,"title":["Combined application of <scp>Er<\/scp>:<scp>YAG<\/scp> and <scp>Nd<\/scp>:<scp>YAG<\/scp> lasers in treatment of chronic periodontitis. A split\u2010mouth, single\u2010blind, randomized controlled trial"],"prefix":"10.1111","volume":"52","author":[{"given":"M.","family":"Sa\u011flam","sequence":"first","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Izmir Katip Celebi University  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"K\u00f6seo\u011flu","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Izmir Katip Celebi University  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130.","family":"Ta\u015fdemir","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Izmir Katip Celebi University  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Erbak Y\u0131lmaz","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry School of Medicine Izmir Katip Celebi University  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Savran","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Izmir Katip Celebi University  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"S\u00fct\u00e7\u00fc","sequence":"additional","affiliation":[{"name":"9242\/1 Street, Apartment No: 5 Karaba\u011flar Izmir 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