{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T05:47:01Z","timestamp":1769147221160,"version":"3.49.0"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,3,27]],"date-time":"2017-03-27T00:00:00Z","timestamp":1490572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["KAKENHI Grant Number 25293424"],"award-info":[{"award-number":["KAKENHI Grant Number 25293424"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>Tissue engineering by using recombinant human (rh) growth factor technology may offer a promising therapeutic approach for treatment of gingival recession. Fibroblast growth factor\u20102 (FGF\u20102) has shown the ability to promote periodontal regeneration. Gelatin\/beta\u2010tricalcium phosphate (gelatin\/\u03b2\u2010TCP) sponges have been developed to control the release of growth factors. The present study evaluated the periodontal regenerative efficacy of rhFGF\u20102 by comparing gelatin\/\u03b2\u2010TCP sponges incorporated with rhFGF\u20102 to the scaffolds alone in artificially created recession\u2010type defects in dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Critically sized buccal gingival recession defects were surgically created on maxillary canine teeth of five dogs. In each animal, defects were randomized to receive either a gelatin\/\u03b2\u2010TCP sponge soaked with rhFGF\u20102 (gelatin\/\u03b2\u2010TCP\/rhFGF\u20102) or phosphate\u2010buffered saline (gelatin\/\u03b2\u2010TCP). Eight weeks after surgery, biopsy specimens were obtained and subjected to microcomputed tomography and histological analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Complete root coverage was achieved in both groups. Microcomputed tomography revealed significantly greater new bone volume in the gelatin\/\u03b2\u2010TCP\/rhFGF\u20102 group. Histologically, both groups achieved periodontal regeneration; however, gelatin\/\u03b2\u2010TCP\/rhFGF\u20102 sites exhibited more tissue regeneration, characterized by significantly larger amounts of new cementum and new bone. Gelatin\/\u03b2\u2010TCP sites featured increased long junctional epithelium and connective tissue attachment. In the gelatin\/\u03b2\u2010TCP\/rhFGF\u20102 sites, new bone exhibited many haversian canals and circumferential lamellae as well as remarkably thick periosteum with blood vascularization and hypercellularity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Within the limitations of this study, rhFGF\u20102 in gelatin\/\u03b2\u2010TCP sponges exhibits an increased potential to support periodontal wound healing\/regeneration in canine recession\u2010type defects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12456","type":"journal-article","created":{"date-parts":[[2017,3,27]],"date-time":"2017-03-27T09:47:43Z","timestamp":1490608063000},"page":"863-871","source":"Crossref","is-referenced-by-count":18,"title":["Biodegradable gelatin\/beta\u2010tricalcium phosphate sponges incorporating recombinant human fibroblast growth factor\u20102 for treatment of recession\u2010type defects: A split\u2010mouth study in dogs"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0612-1375","authenticated-orcid":false,"given":"A.","family":"Shujaa Addin","sequence":"first","affiliation":[{"name":"Department of Periodontology Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University   Tokyo  Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Akizuki","sequence":"additional","affiliation":[{"name":"Department of Periodontology Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University   Tokyo  Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Hoshi","sequence":"additional","affiliation":[{"name":"Department of Periodontology Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University   Tokyo  Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Matsuura","sequence":"additional","affiliation":[{"name":"Department of Periodontology Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University   Tokyo  Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Ikawa","sequence":"additional","affiliation":[{"name":"Department of Periodontology Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University   Tokyo  Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Fukuba","sequence":"additional","affiliation":[{"name":"Department of Periodontology Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University   Tokyo  Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Matsui","sequence":"additional","affiliation":[{"name":"Polymer Chemistry Division Chemical Resources Laboratory Tokyo Institute 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