{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T06:17:00Z","timestamp":1761718620419,"version":"3.37.3"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,9,5]],"date-time":"2017-09-05T00:00:00Z","timestamp":1504569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:p>Adjunctive therapeutic agents may be used to improve the response to nonsurgical periodontal therapy. Local delivery of statins (simvastatin, artovastatin and rosuvastatin) is a promising adjunct to scaling and root planing (<jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>). Thus, the aim of this review is to evaluate if adjunctive local delivery of statins is more effective than<jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>alone. Randomized clinical trials that presented a test group evaluating local delivery of statins as adjuncts in healthy, diabetic and smoking patients were included. Medline and the Cochrane library database were searched up to November 2016. Random effects meta\u2010analyses were conducted for pocket depth change and clinical attachment gain. One hundred and twenty\u2010five studies potentially related to the aim of this review were screened, but only 10 were included. The majority of the trials reported additional clinical benefits in the groups that were treated with adjunctive local delivery of statins. Pooled calculations showed that local delivery of statins resulted in additional reduction of pocket depth and clinical attachment gain in healthy people, smokers and diabetic patients. Local statins may offer additional clinical benefits to<jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>, even in smokers and diabetics.<\/jats:p>","DOI":"10.1111\/jre.12480","type":"journal-article","created":{"date-parts":[[2017,9,5]],"date-time":"2017-09-05T10:51:25Z","timestamp":1504608685000},"page":"12-21","source":"Crossref","is-referenced-by-count":14,"title":["Does the adjunctive use of statins provide additional benefits to nonsurgical periodontal treatment? A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2494-1513","authenticated-orcid":false,"given":"L. M. B.","family":"Ambr\u00f3sio","sequence":"first","affiliation":[{"name":"Department of Stomatology Division of Periodontics Faculty of Dentistry University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. 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