{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T05:12:10Z","timestamp":1789881130796,"version":"4.0.1"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470751"],"award-info":[{"award-number":["81470751"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81222011"],"award-info":[{"award-number":["81222011"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>The efficacy and outcomes of aspirin in local defects and the use of platelet\u2010rich fibrin (<jats:styled-content style=\"fixed-case\">PRF<\/jats:styled-content>) in periodontal defects were investigated. Whether the <jats:styled-content style=\"fixed-case\">PRF<\/jats:styled-content>\/aspirin complex is a suitable scaffold and delivery system to carry sustained\u2010release aspirin\/salicylic acid to promote periodontal bone regeneration was determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>PRF and <jats:styled-content style=\"fixed-case\">PRF<\/jats:styled-content>\/aspirin complex were prepared. The concentrations of aspirin\/salicylic acid released from the <jats:styled-content style=\"fixed-case\">PRF<\/jats:styled-content>\/aspirin complex were calculated at 37\u00b0C. Periodontal ligament mesenchymal cells were cultured on six\u2010well plates with <jats:styled-content style=\"fixed-case\">PRF<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">PRF<\/jats:styled-content>\/aspirin complex gel to analyze proliferation and migration. The alveolar bone between the inferior buccal mesial root and anterior buccal distal root of the first maxillary molar was removed in 15 rats randomly divided into three groups: no treatment, <jats:styled-content style=\"fixed-case\">PRF<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">PRF<\/jats:styled-content>\/aspirin complex. Twelve weeks post\u2010transplantation, 2D\/3D micro\u2010computed tomography and histomorphometric technique were used for quantitative analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The PRF\/aspirin complex provided a sustained\u2010release aspirin\/salicylic acid. Peak concentrations occurred 4\u00a0hours after transplantation and were sustained to 48\u00a0hours at 37\u00b0C; the total concentration of released aspirin\/salicylic acid was 83.5\u00a0mg\/mL, respectively. The sustained\u2010release promoted the proliferation and migration of periodontal ligament mesenchymal cells. Micro\u2010computed tomography and histological data showed that both the <jats:styled-content style=\"fixed-case\">PRF<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PRF<\/jats:styled-content>\/aspirin complex enhanced periodontal bone formation (<jats:italic>P<\/jats:italic>&lt;.05). Moreover, the new bone formation was two times greater in the <jats:styled-content style=\"fixed-case\">PRF<\/jats:styled-content>\/aspirin complex group than the <jats:styled-content style=\"fixed-case\">PRF<\/jats:styled-content> group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Aspirin\/salicylic acid could be sustained\u2010released from PRF\/aspirin complex, which could inhibit inflammation and improve the function of mesenchymal cells. The data might provide a new safe and easy clinical therapeutic strategy to promote periodontal bone reparation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12485","type":"journal-article","created":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T12:28:38Z","timestamp":1504268918000},"page":"47-56","source":"Crossref","is-referenced-by-count":48,"title":["Platelet\u2010rich fibrin\/aspirin complex promotes alveolar bone regeneration in periodontal defect in rats"],"prefix":"10.1111","volume":"53","author":[{"given":"J.","family":"Du","sequence":"first","affiliation":[{"name":"Laboratory of Tissue Regeneration and Immunology and Department of Periodontics Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction School of Stomatology Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Mei","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Beijing Tiantan Hospital Capital Medical 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