{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T18:42:20Z","timestamp":1767984140737,"version":"3.49.0"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,9,4]],"date-time":"2017-09-04T00:00:00Z","timestamp":1504483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"University of Otago Fuller grant"},{"name":"Molteno\u00ae Ophthalmic Ltd"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>The aim of this pilot study was to characterize surface morphology and to evaluate resorption and osseous healing of two deproteinated bovine bone graft materials after sinus grafting in a large animal model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Surfaces of a novel particulate bovine bone graft, Moa\u2010Bone<jats:sup>\u00ae<\/jats:sup> were compared with Bio\u2010Oss<jats:sup>\u00ae<\/jats:sup> using scanning electron microscopy. Six sheep then had maxillary sinus grafting bilaterally, covered with BioGide<jats:sup>\u00ae<\/jats:sup>. Grafted maxillae were harvested after 4, 6 and 12\u00a0weeks. Healing was described for half of each site using resin\u2010embedded ground sections. For the other half, paraffin\u2010embedded sections were examined using tartrate resistant acid phosphatase staining for osteoclast activity, <jats:styled-content style=\"fixed-case\">runt\u2010related transcription factor<\/jats:styled-content>2 immunohistochemistry for pre\u2010osteoblasts and osteoblasts and <jats:styled-content style=\"fixed-case\">proliferating cell nuclear antigen<\/jats:styled-content> for proliferative cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Moa\u2010Bone<jats:sup>\u00ae<\/jats:sup> had a smoother, more porous fibrous structure with minimal globular particles compared with Bio\u2010Oss<jats:sup>\u00ae<\/jats:sup>. After 4\u00a0weeks, woven bone formed on both grafts and the Moa\u2010Bone<jats:sup>\u00ae<\/jats:sup> particles also showed signs of resorption. After 12\u00a0weeks, Moa\u2010Bone<jats:sup>\u00ae<\/jats:sup> continued to be resorbed, however Bio\u2010Oss<jats:sup>\u00ae<\/jats:sup> did not; both grafts were surrounded by maturing lamellar bone. Moa\u2010Bone<jats:sup>\u00ae<\/jats:sup> was associated with earlier evidence of runt\u2010related transcription factor 2\u2010positive cells. Moa\u2010Bone<jats:sup>\u00ae<\/jats:sup> but not Bio\u2010Oss<jats:sup>\u00ae<\/jats:sup> was associated with strong <jats:styled-content style=\"fixed-case\">tartrate resistant acid phosphatase<\/jats:styled-content>\u2010positive osteoclasts on the graft surface within resorption lacunae at both 4 and 6\u00a0weeks post\u2010grafting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Both materials supported osseous healing and maturation without inflammation. Moa\u2010Bone<jats:sup>\u00ae<\/jats:sup> showed marked osteoclast activity after 4 and 6\u00a0weeks and demonstrated positive attributes for grafting, if complete remodeling of the graft within the site is desired. Further optimization of Moa\u2010Bone<jats:sup>\u00ae<\/jats:sup> for maxillofacial applications is warranted.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12490","type":"journal-article","created":{"date-parts":[[2017,9,4]],"date-time":"2017-09-04T06:16:44Z","timestamp":1504505804000},"page":"80-90","source":"Crossref","is-referenced-by-count":17,"title":["Attributes of Bio\u2010Oss<sup>\u00ae<\/sup> and Moa\u2010Bone<sup>\u00ae<\/sup> graft materials in a pilot study using the sheep maxillary sinus model"],"prefix":"10.1111","volume":"53","author":[{"given":"M. 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