{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:14:51Z","timestamp":1780359291618,"version":"3.54.1"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,11,15]],"date-time":"2017-11-15T00:00:00Z","timestamp":1510704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP25870198"],"award-info":[{"award-number":["JP25870198"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP15K20616"],"award-info":[{"award-number":["JP15K20616"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP16H05824"],"award-info":[{"award-number":["JP16H05824"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005957","name":"8020 Promotion Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007434","name":"Suzuken Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007434","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007325","name":"Kobayashi International Scholarship Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007325","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007716","name":"Banyu Life Science Foundation International","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007716","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>It is well known that there is a strong relationship between periodontitis and cardiovascular disease (<jats:styled-content style=\"fixed-case\">CVD)<\/jats:styled-content>. Tooth loss reflects an end\u2010stage condition of oral diseases, such as periodontitis. Infection with specific periodontal pathogens is known as a possible factor that influences development of <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>. The aim of this study was to assess the relationship between the number of residual teeth and systemic inflammatory conditions in patients with <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>We divided 364 patients with <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content> into four groups, according to the number of residual teeth: (i) \u226520 teeth; (ii) 10\u201019 teeth; (iii) 1\u20109 teeth; and (iv) edentulous. We recorded medical history, blood data and periodontal conditions. Serum samples were obtained and their IgG titers against three major periodontal pathogens were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Smoking rate and the prevalence of diabetes mellitus were higher in edentulous patients and in subjects with a few teeth compared with patients with many teeth. The levels of C\u2010reactive protein were higher in patients with 1\u20109 teeth than in those with 10\u201019 teeth and with \u226520 teeth. The level of <jats:italic>Porphyromonas gingivalis<\/jats:italic> IgG in the group with 10\u201019 teeth was statistically higher than that in the group with \u226520 teeth. The level of <jats:italic>P. gingivalis<\/jats:italic> IgG in the edentulous group tended to be lower than that in the other groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The patients with 1\u20109 teeth had the highest level of C\u2010reactive protein among the four groups, and the patients with 10\u201019 teeth had the highest level of IgG to periodontal bacteria. We conclude that the number of remaining teeth may be used to estimate the severity of systemic inflammation in patients with <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12494","type":"journal-article","created":{"date-parts":[[2017,11,15]],"date-time":"2017-11-15T12:20:13Z","timestamp":1510748413000},"page":"117-122","source":"Crossref","is-referenced-by-count":25,"title":["Associations among tooth loss, systemic inflammation and antibody titers to periodontal pathogens in Japanese patients with cardiovascular disease"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8498-4494","authenticated-orcid":false,"given":"N.","family":"Aoyama","sequence":"first","affiliation":[{"name":"Division of Periodontology Department of Oral Interdisciplinary Medicine Graduate School of Dentistry Kanagawa Dental University  Yokosuka Japan"},{"name":"Department of Periodontology Graduate School of 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