{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T20:11:14Z","timestamp":1779912674665,"version":"3.53.1"},"reference-count":52,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,11,5]],"date-time":"2017-11-05T00:00:00Z","timestamp":1509840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["R01DE019456"],"award-info":[{"award-number":["R01DE019456"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:p>Aggressive periodontitis is a rare but rapidly progressing form of periodontal disease that usually affects otherwise systemically healthy individuals, at a young age. It usually affects first molars and incisors, which are usually lost if treatment is not properly and early rendered. Although of low prevalence, it affects individuals of African descent at a higher prevalence, and usually multiple members within the same family. Several studies have been performed in the attempt to evaluate specific single nucleotide polymorphisms (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s) that could be associated with this disease. To the best of our knowledge, the present article provides the first review of the literature focusing on studies that evaluated <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s in patients of African descent with aggressive periodontitis. Several <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s have been evaluated in different genes according to their role in the pathogenesis of the disease, with positive and negative associations (such as <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>1<\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">FCGR<\/jats:styled-content>3B<\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">FPR<\/jats:styled-content>1<\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">LTF<\/jats:styled-content><\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">CYBA<\/jats:styled-content><\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">GLT<\/jats:styled-content>6D1<\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>4<\/jats:italic>) with both the localized and generalized forms of aggressive periodontitis. Given the complexity of periodontitis, the difficulty in gathering large cohorts diagnosed with this rare form of disease, and the fact that candidate gene studies may only determine part of the genetic risk of a disease, the search for specific <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s associated with aggressive periodontitis seems to be a long one, most likely to result in the combination of multiple <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s, in multiple genes.<\/jats:p>","DOI":"10.1111\/jre.12505","type":"journal-article","created":{"date-parts":[[2017,11,6]],"date-time":"2017-11-06T04:56:40Z","timestamp":1509944200000},"page":"164-173","source":"Crossref","is-referenced-by-count":25,"title":["Genetic polymorphisms and periodontal disease in populations of African descent: A review"],"prefix":"10.1111","volume":"53","author":[{"given":"P. F.","family":"Gon\u00e7alves","sequence":"first","affiliation":[{"name":"Department of Periodontology College of Dentistry University of Florida  Gainesville FL USA"},{"name":"Department of Dentistry Federal University of Jequitinhonha and Mucuri Valleys  Diamantina MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. H.","family":"Harris","sequence":"additional","affiliation":[{"name":"Department of Periodontology College of Dentistry University of Florida  Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Elmariah","sequence":"additional","affiliation":[{"name":"Department of Periodontology College of Dentistry University of Florida  Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Aukhil","sequence":"additional","affiliation":[{"name":"Department of Periodontology College of Dentistry University of Florida  Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. R.","family":"Wallace","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Microbiology College of Medicine University of Florida  Gainesville FL USA"},{"name":"University of Florida Genetics Institute University of Florida  Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0948-1667","authenticated-orcid":false,"given":"L. 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