{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T19:00:17Z","timestamp":1770231617421,"version":"3.49.0"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,10,31]],"date-time":"2017-10-31T00:00:00Z","timestamp":1509408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ftirma Kurumu","doi-asserted-by":"publisher","award":["213S105"],"award-info":[{"award-number":["213S105"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004935","name":"S\u00fcleyman Demirel \u00dcniversitesi","doi-asserted-by":"publisher","award":["3424\u2010D1\u201013"],"award-info":[{"award-number":["3424\u2010D1\u201013"]}],"id":[{"id":"10.13039\/501100004935","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2018,4]]},"abstract":"Background and Objective<\/jats:title>Nitric oxide is a free radical that is synthesized from l<\/jats:sc>\u2010arginine by nitric oxide synthase (NOS<\/jats:styled-content>). The level of inducible NOS<\/jats:styled-content> (iNOS<\/jats:styled-content>) in gingiva with periodontitis is higher than that in healthy gingiva. The aim of this study was to evaluate the effects of rosuvastatin administration on alveolar bone loss (ABL)<\/jats:styled-content> and iNOS<\/jats:styled-content>(+) cell counts in gingival tissues in rats with ligature\u2010induced experimental periodontitis with\/without hyperlipidaemia.<\/jats:p><\/jats:sec>Material and Methods<\/jats:title>The rats were randomly divided into seven groups: Hy (cholesterol\u2010added diet\/water administration); HyP (cholesterol\u2010added diet\/periodontitis\/water administration); HyPR (cholesterol\u2010added diet\/periodontitis\/rosuvastatin administration); P (standard diet\/periodontitis\/water administration); PR (standard diet\/periodontitis\/rosuvastatin administration); C (standard diet\/water administration); and R (standard diet\/rosuvastatin administration). Experimental periodontitis was induced with silk ligatures, and rosuvastatin\/water was administered to rats by oral gavage for the last 2\u00a0weeks of the 8\u2010week study. After the rats were killed in week 8, histomorphometric and histological analyses were performed. Immunostained iNOS<\/jats:styled-content>(+) cells were counted in the gingival samples and the Mann\u2010Whitney U<\/jats:italic>\u2010test was used for statistical analysis.<\/jats:p><\/jats:sec>Results<\/jats:title>The experimental groups exhibited increases in total cholesterol and low\u2010density lipoprotein, except for Groups C and R. The cholesterol\u2010added diet induced ABL<\/jats:styled-content> in Group Hy. Of the periodontitis groups, the lowest ABL<\/jats:styled-content> was found in Group PR<\/jats:styled-content>. While there was a significant difference in ABL<\/jats:styled-content> between Groups P (0.82\u00a0\u00b1\u00a00.15\u00a0mm) and PR<\/jats:styled-content> (0.70\u00a0\u00b1\u00a00.21\u00a0mm) receiving a standard diet (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>.05), no difference was observed between Groups HyP (0.77\u00a0\u00b1\u00a00.07\u00a0mm) and HyPR<\/jats:styled-content> (0.76\u00a0\u00b1\u00a00.11\u00a0mm) receiving a cholesterol\u2010added diet (P<\/jats:italic>\u00a0\u02c3\u00a0.05). Rosuvastatin significantly reduced expression of iNOS<\/jats:styled-content> in Groups PR<\/jats:styled-content> (18.40\u00a0\u00b1\u00a02.31%) and HyPR<\/jats:styled-content> (24.00\u00a0\u00b1\u00a04.83%) compared with Group P (30.90\u00a0\u00b1\u00a02.42%; P\u00a0<\/jats:italic><\u00a0<\/jats:italic>.001). However, a larger number of iNOS<\/jats:styled-content>(+) cells was found in Group HyPR<\/jats:styled-content> than in Group PR<\/jats:styled-content> (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>.001).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Administration of rosuvastatin reduced gingival iNOS<\/jats:styled-content> expression in ligature\u2010induced periodontitis with\/without hyperlipidaemia. It also led to significant differences in ABL<\/jats:styled-content> in rats with periodontitis, except when periodontitis was associated with hyperlipidaemia. These findings could provide an important contribution in further studies to evaluate the role of rosuvastatin as a host modulatory agent in the pathogenesis of periodontal diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12513","type":"journal-article","created":{"date-parts":[[2017,10,31]],"date-time":"2017-10-31T05:38:36Z","timestamp":1509428316000},"page":"258-266","source":"Crossref","is-referenced-by-count":16,"title":["Effects of rosuvastatin on inducible nitric oxide synthase in rats with hyperlipidaemia and periodontitis"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5240-4504","authenticated-orcid":false,"given":"F. Y.","family":"K\u0131rz\u0131o\u011flu","sequence":"first","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry S\u00fcleyman Demirel University Isparta Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6.","family":"\u00d6zmen","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculty of Veterinary Medicine Mehmet Akif Ersoy University Burdur Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Do\u011fan","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Mustafa Kemal University Hatay Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. T.","family":"Bulut","sequence":"additional","affiliation":[{"name":"Private Elitia Oral and Dental Health Polyclinic Alanya \u2013 Antalya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2138-2004","authenticated-orcid":false,"given":"\u00d6.","family":"Fento\u011flu","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry S\u00fcleyman Demirel University Isparta Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"\u00d6zdem","sequence":"additional","affiliation":[{"name":"Private Clinic Bolu 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