{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T15:36:01Z","timestamp":1783092961406,"version":"3.54.6"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>To the best of our knowledge, the healing time for toothbrush\u2010induced gingival abrasions in humans has not yet been explored. The aim of this study was to evaluate the time needed to heal for toothbrush\u2010induced abrasions of the keratinized mucosa of the palate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>In patients without, with mild periodontitis or with periodontitis, gingival abrasion lesions were induced at the keratinized mucosa of the palate by brushing up to 2\u00a0minutes. Healing as observed clinically was followed via calibrated digital photographs of the lesion after staining, every 24\u00a0hours until the lesion had resolved. In patients without or with only mild periodontitis, the healing time of lesions caused by 30\u00a0seconds and 1\u00a0minute of brushing was also recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010one participants (11 without or with mild periodontitis, 20 with periodontitis) met the inclusion criteria. In patients without or with mild periodontitis, the lesions induced by brushing for 2\u00a0minutes diminished by 48.7% of their original surface area within 24\u00a0hours. In patients with periodontitis the respective outcome was 45.4% (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.87). Abrasions caused by 2\u00a0minutes of brushing needed more than 24\u00a0hours to heal completely. When decreasing the time exposed to trauma, fewer lesions were visible at baseline and the time needed to heal decreased. The subgroup of smokers was too small to evaluate any effect.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The longer the exposure time of the keratinized mucosa of the palate to trauma, the more lesions were visible, the larger the abrasions were and the more time they needed to heal completely. More studies are needed to investigate the role of smoking, gingival biotype and to link these findings with gingival recessions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12540","type":"journal-article","created":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T05:52:43Z","timestamp":1519883563000},"page":"506-513","source":"Crossref","is-referenced-by-count":2,"title":["Healing of toothbrush\u2010induced abrasions to keratinized mucosa of the palate in humans: A pilot study"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0441-9066","authenticated-orcid":false,"given":"M.","family":"De Nutte","sequence":"first","affiliation":[{"name":"Department of Oral Health Sciences KU Leuven &amp; Dentistry University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Behaeghe","sequence":"additional","affiliation":[{"name":"Department of Oral Health Sciences KU Leuven &amp; Dentistry University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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