{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T08:43:15Z","timestamp":1781685795444,"version":"3.54.5"},"reference-count":66,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T00:00:00Z","timestamp":1522368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2018,8]]},"abstract":"Background and Objective<\/jats:title>Full\u2010mouth scaling and root planing (FM<\/jats:styled-content>\u2010SRP<\/jats:styled-content>) acts as a potent inflammatory stimulus immediately after treatment; however, systemic inflammation typically improves in the long term. The contribution of FM<\/jats:styled-content>\u2010SRP<\/jats:styled-content> to systemic biological and acute\u2010phase responses is largely unknown. The purpose of this prospective intervention study was to assess the systemic and local biological responses after FM<\/jats:styled-content>\u2010SRP<\/jats:styled-content>.<\/jats:p><\/jats:sec>Material and Methods<\/jats:title>Thirty\u2010one patients with generalized moderate\u2010to\u2010severe chronic periodontitis received 1\u2010stage FM<\/jats:styled-content>\u2010SRP<\/jats:styled-content>. Measurement of clinical parameters and body temperature as well as collection of subgingival plaque, peripheral blood and gingival crevicular fluid was performed before and after treatment 2 or 3 times. Quantification of periodontopathic bacteria in the sulcus and measurement of corresponding serum IgG titers were performed. Systemic and local inflammatory markers such as endotoxin, high\u2010sensitive C\u2010reactive protein (hs\u2010CRP<\/jats:styled-content>) and 6 inflammatory cytokines were assessed using high\u2010sensitivity assays.<\/jats:p><\/jats:sec>Results<\/jats:title>Compared to baseline values, FM<\/jats:styled-content>\u2010SRP<\/jats:styled-content> resulted in a substantial improvement in clinical parameters (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>.05), lower bacterial counts (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>.01) and a significant decrease of IgG titers against Porphyromonas gingivalis<\/jats:italic> (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>.001) 6\u00a0weeks after treatment. Comparing baseline parameters to those at 1\u00a0day post\u2010treatment, there was a statistically significant elevation in body temperature (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>.007). In addition, a 5\u2010fold increase in hs\u2010CRP<\/jats:styled-content> (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>.001), a remarkable increase in interferon\u2010\u03b3 (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>.001) and a slight increase in interleukin (IL)<\/jats:styled-content>\u201012p70 (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>.001) were detected in serum samples. In the gingival crevicular fluid, marked increases in hs\u2010CRP<\/jats:styled-content> (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>.001), IL<\/jats:styled-content>\u20105 (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>.001), IL<\/jats:styled-content>\u20106, IL<\/jats:styled-content>\u201012p70 and tumor necrosis factor\u2010\u03b1 (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>.001 for the latter 3 markers) were noted 1\u00a0day after treatment. Endotoxin levels were below measurable limits for most time points.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>FM<\/jats:styled-content>\u2010SRP<\/jats:styled-content> resulted in clinical and microbiological improvement 6\u00a0weeks post\u2010treatment, but produced a moderate systemic acute\u2010phase response including elevated inflammatory mediators 1\u00a0day post\u2010treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12543","type":"journal-article","created":{"date-parts":[[2018,3,31]],"date-time":"2018-03-31T10:41:17Z","timestamp":1522492877000},"page":"536-544","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Increased systemic levels of inflammatory mediators following one\u2010stage full\u2010mouth scaling and root 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