{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T01:23:57Z","timestamp":1776129837724,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T00:00:00Z","timestamp":1523836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>The aim of this study was to describe the radiographic features of the first molars of patients with localized aggressive periodontitis (<jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>gP) and of their associated intrabony defects and to compare them with a control sample of chronic periodontitis cases and healthy subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from a total of 93 patients were included in this analysis. First, dental panoramic tomograms of 34 patients with <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>gP (131 first molars) and 30 periodontally healthy patients (110 first molars) were compared. Then, periapical radiographs of the first molars of the same patients with <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>gP and of 29 patients with chronic periodontitis affected by intrabony defects were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Shorter root trunks were associated with the presence of intrabony defects in patients with <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>gP (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.002 at multilevel logistic regression), also when <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>gP molars were compared with healthy subjects (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.036). Although no difference in defect depth and angle was noted between <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>gP and <jats:styled-content style=\"fixed-case\">chronic periodontitis<\/jats:styled-content> intrabony defects, <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>gP intrabony defects appeared to be more frequently symmetrical and arch\u2010shaped than in <jats:styled-content style=\"fixed-case\">chronic periodontitis<\/jats:styled-content> (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.008), with positive predictive value and negative predictive value of for \u2018wide arch\u2019 defect of 87.3% (95% CI\u00a0=\u00a077.2%\u201093.3%) and 32.3% (95% CI\u00a0=\u00a027.7%\u201037.2%) respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>First molars of patients with <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>gP affected by intrabony defects may have some distinct radiographic anatomical characteristics to those of healthy subjects. The shape of intrabony defects seems to differ between <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>gP and <jats:styled-content style=\"fixed-case\">chronic periodontitis<\/jats:styled-content> cases. Further studies need to confirm these features and investigate if they are related to the initiation and progression of periodontitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12548","type":"journal-article","created":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T23:41:36Z","timestamp":1523922096000},"page":"582-588","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Radiographic morphology of intrabony defects in the first molars of patients with localized aggressive periodontitis: Comparison with health and chronic periodontitis"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7750-5010","authenticated-orcid":false,"given":"L.","family":"Nibali","sequence":"first","affiliation":[{"name":"Centre for Immunobiology &amp; Regenerative Medicine Centre for Oral Clinical Research Institute of Dentistry Bart's and the London School of Medicine and Dentistry Queen Mary University of London (QMUL)  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Tomlins","sequence":"additional","affiliation":[{"name":"Bart's and the London School of Medicine and Dentistry Queen Mary University of London (QMUL)  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Akcal\u0131","sequence":"additional","affiliation":[{"name":"Centre for Immunobiology &amp; Regenerative Medicine Centre for Oral Clinical Research Institute of Dentistry Bart's and the London School of Medicine and Dentistry Queen Mary University of London (QMUL)  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,4,16]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.53"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1993.tb01756.x"},{"key":"e_1_2_5_4_1","first-page":"345","article-title":"Localized aggressive periodontitis in a six\u2010year\u2010old: a case report","volume":"26","author":"Hilgers KK","year":"2004","journal-title":"Pediatr Dent"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1974.45.8.2.636"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.1993.tb00753.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2014.140171"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2000.2220102.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1983.tb01293.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2010.00359.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60135-X"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00729-13"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2012.10.009"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2009.00325.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.8.1052"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.1.66"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016358609004739"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1995.tb00129.x"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.17796\/1053-4628-42.2.3"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.00952.x"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12653"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.38"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00822.x"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.1986.tb00119.x"},{"key":"e_1_2_5_25_1","first-page":"188","article-title":"Alveolar bone height of primary and first permanent molars in healthy seven\u2010 to nine\u2010year\u2010old children","volume":"64","author":"Needleman HL","year":"1997","journal-title":"ASDC J Dent Child"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1984.55.10.604"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.5051\/jpis.2015.45.1.2"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2009.01526.x"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2007.01039.x"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2001.280803.x"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1987.58.10.715"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6979.2004.00455.x"}],"container-title":["Journal of Periodontal Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjre.12548","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jre.12548","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T04:54:08Z","timestamp":1695012848000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jre.12548"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,16]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.1111\/jre.12548"],"URL":"https:\/\/doi.org\/10.1111\/jre.12548","archive":["Portico"],"relation":{},"ISSN":["0022-3484","1600-0765"],"issn-type":[{"value":"0022-3484","type":"print"},{"value":"1600-0765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,16]]},"assertion":[{"value":"2018-02-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}