{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T05:38:48Z","timestamp":1769319528723,"version":"3.49.0"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,5,6]],"date-time":"2018-05-06T00:00:00Z","timestamp":1525564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005971","name":"Deutsche Herzstiftung","doi-asserted-by":"publisher","award":["F\/34\/08"],"award-info":[{"award-number":["F\/34\/08"]}],"id":[{"id":"10.13039\/501100005971","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2018,10]]},"abstract":"Background and Objective<\/jats:title>Biological plausibility of an association between severe periodontitis and cardiovascular disease (CVD) has been proven. Genetic characteristics play an important role in both complex inflammatory diseases. Polymorphisms (single nucleotide polymorphisms [SNP<\/jats:styled-content>s]) in the long noncoding RNA,<\/jats:styled-content> antisense noncoding RNA<\/jats:styled-content> in the INK<\/jats:styled-content>4<\/jats:italic> locus (ANRIL),<\/jats:styled-content> were shown to play a leading role in both diseases. The primary objectives of the study were to assess, among cardiovascular (CV angiographically proven \u226550% stenosis of a main coronary artery) patients, the impact of ANRIL SNP<\/jats:styled-content>s rs133049 and rs3217992 on the severity of periodontitis and the previous history of coronary events, as well as on the occurrence of further adverse CV events.<\/jats:p><\/jats:sec>Material and Methods<\/jats:title>The prevalence of severe periodontitis was analyzed in 1002 CV<\/jats:styled-content> patients. ANRIL SNP<\/jats:styled-content>s rs133049 and rs3217992 were genotyped. The prognostic value of both ANRIL SNP<\/jats:styled-content>s for combined CV endpoint (stroke\/transient ischemic attack [TIA]<\/jats:styled-content>, myocardial infarction, death from a CV\u2010related event, death from stroke) was evaluated after a 3\u2010year follow\u2010up period. Hazard ratios (HR<\/jats:styled-content>s) were adjusted for established CV risk factors applying Cox regression.<\/jats:p><\/jats:sec>Results<\/jats:title>ANRIL SNP<\/jats:styled-content>s rs133049 and rs3217992 were not associated with severe periodontitis or history of CVD in CV<\/jats:styled-content> patients. In the Kaplan\u2010Meier survival curve including the log rank\u2010test (P<\/jats:italic>\u00a0=\u00a0.036) and Cox regression (hazard ratio = 1.684, P<\/jats:italic>\u00a0=\u00a0.009) the AA<\/jats:styled-content> genotype of rs3217992 was shown to be an independent predictor for adverse CV events after 3\u00a0years of follow\u2010up.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>SNP<\/jats:styled-content>s in ANRIL<\/jats:styled-content> are not risk modulators for severe periodontitis and history of CVD<\/jats:styled-content> in CV<\/jats:styled-content> patients. The AA<\/jats:styled-content> genotype of ANRIL SNP<\/jats:styled-content>s rs3217992 possesses prognostic power for further CV events within 3\u00a0years of follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12555","type":"journal-article","created":{"date-parts":[[2018,5,7]],"date-time":"2018-05-07T04:29:59Z","timestamp":1525667399000},"page":"714-720","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Single nucleotide polymorphisms<\/scp> in long noncoding RNA<\/scp>, ANRIL<\/scp>, are not associated with severe periodontitis but with adverse cardiovascular events among patients with cardiovascular disease"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4541-666X","authenticated-orcid":false,"given":"S.","family":"Schulz","sequence":"first","affiliation":[{"name":"Department of Operative Dentistry and Periodontology Martin Luther\u2010University Halle\u2010Wittenberg 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