{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:11:16Z","timestamp":1789495876968,"version":"build-2803163510"},"reference-count":56,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,6,2]],"date-time":"2018-06-02T00:00:00Z","timestamp":1527897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>This study aims to evaluate the use of the leukocyte\u2010 and platelet\u2010rich fibrin (L\u2010<jats:styled-content style=\"fixed-case\">PRF)<\/jats:styled-content> membranes in increasing the width of the keratinized mucosa (<jats:styled-content style=\"fixed-case\">KM<\/jats:styled-content>) around implants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Eight patients in need for bilateral widening of the <jats:styled-content style=\"fixed-case\">KM<\/jats:styled-content> around implants in the lower jaw were recruited for a spit\u2010mouth randomized controlled trial. At the control site, a free gingival graft (<jats:styled-content style=\"fixed-case\">FGG<\/jats:styled-content>) was used, whereas at the other side (test), L\u2010<jats:styled-content style=\"fixed-case\">PRF<\/jats:styled-content> membranes were applied. The primary outcome was the increase in width of <jats:styled-content style=\"fixed-case\">KM<\/jats:styled-content> around the implants. As secondary outcomes, the postoperative pain and surgical time were assessed. The follow\u2010up period was 6\u00a0weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A significant increase in the total bucco\u2010lingual width of <jats:styled-content style=\"fixed-case\">KM<\/jats:styled-content> in both groups was observed, with 1.3\u00a0mm\u00a0\u00b1\u00a00.9 extra gain (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05) for the <jats:styled-content style=\"fixed-case\">FGG<\/jats:styled-content> sites. Shrinkage of the widened areas in this period was 32.1% at the test site and 23.6% at the control site. All values of the postoperative pain scores at the control site were higher than at the test site. The mean surgery time in the test and control group was 29.1\u00a0\u00b1\u00a04.8 and 48.1\u00a0\u00b1\u00a07.7\u00a0minutes, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Within the limitations of this randomized controlled trial with split mouth design, it can be concluded that L\u2010<jats:styled-content style=\"fixed-case\">PRF<\/jats:styled-content> can increase the width of <jats:styled-content style=\"fixed-case\">KM<\/jats:styled-content> around implants. Furthermore, the use of L\u2010<jats:styled-content style=\"fixed-case\">PRF<\/jats:styled-content> results in a lower surgical time with less postoperative discomfort and pain for the patients in comparison to the <jats:styled-content style=\"fixed-case\">FGG<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12568","type":"journal-article","created":{"date-parts":[[2018,6,2]],"date-time":"2018-06-02T13:05:33Z","timestamp":1527944733000},"page":"793-800","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["L\u2010<scp>PRF<\/scp> for increasing the width of keratinized mucosa around implants: A split\u2010mouth, randomized, controlled pilot clinical trial"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1513-2236","authenticated-orcid":false,"given":"A.","family":"Temmerman","sequence":"first","affiliation":[{"name":"Section of Periodontology Department of Oral Health Sciences KU Leuven &amp; Dentistry University Hospitals KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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