{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T21:36:56Z","timestamp":1781041016307,"version":"3.54.1"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T00:00:00Z","timestamp":1527724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102014R1A4A1005309"],"award-info":[{"award-number":["NRF\u20102014R1A4A1005309"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102014R1A2A1A11051729"],"award-info":[{"award-number":["NRF\u20102014R1A2A1A11051729"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>Phelligridin D is a hispidin analogue from the mushroom <jats:italic>Phellinus baumii<\/jats:italic> that is widely used as a food source in East Asia. This study tested phelligridin D for the anti\u2010inflammatory effect and mechanism in lipopolysaccharide (<jats:styled-content style=\"fixed-case\">LPS)<\/jats:styled-content>\u2010induced human periodontal ligament cells (<jats:styled-content style=\"fixed-case\">HPDLC<\/jats:styled-content>s). The objective of this study was to clarify whether the anti\u2010inflammatory function of phelligridin D affects periodontal regeneration for supporting the <jats:styled-content style=\"fixed-case\">HPDLC<\/jats:styled-content>s of teeth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Primary <jats:styled-content style=\"fixed-case\">HPDLC<\/jats:styled-content>s were isolated from healthy teeth and then cultured. The anti\u2010inflammatory function, mechanism and differentiation molecules were verified with reactive oxygen species generation and western blot analysis in <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>\u2010induced <jats:styled-content style=\"fixed-case\">HPDLC<\/jats:styled-content>s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>HPDLCs showed increased inflammatory molecules (intracellular adhesion molecule\u20101 and vascular cell adhesion molecule\u20101) and decreased osteogenic proteins (bone morphogenetic protein\u20107, Osterix and runt\u2010related transcription factor 2) by <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content> treatment. Phelligridin D decreased inflammatory molecules and increased osteogenic molecules via downregulation of the extracellular signal\u2010regulated kinase and c\u2010jun N\u2010terminal kinases pathway among the mitogen\u2010activated protein kinase, followed by blocking of nuclear factor kappa\u2010B translocation from cytosol to nucleus. In addition, phelligridin D showed antioxidant properties by reducing r<jats:styled-content style=\"fixed-case\">eactive oxygen species<\/jats:styled-content> activity. Finally, the anti\u2010inflammatory and antioxidant function of phelligridin D promoted the periodontal differentiation of <jats:styled-content style=\"fixed-case\">HPDLC<\/jats:styled-content>s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results suggest that phelligridin D supports teeth on the alveolar bone against outside stress, and may be used as an anti\u2010inflammatory compound for the prevention of periodontitis or periodontal regenerative related disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12570","type":"journal-article","created":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T09:45:51Z","timestamp":1527759951000},"page":"816-824","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Anti\u2010inflammatory character of <i>Phelligridin D<\/i> modulates periodontal regeneration in l<scp>ipopolysaccharide<\/scp>\u2010induced human periodontal ligament 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