{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T19:34:28Z","timestamp":1778873668173,"version":"3.51.4"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,10,4]],"date-time":"2018-10-04T00:00:00Z","timestamp":1538611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>Periodontitis in one of the most prevalent dental diseases. Despite numerous studies have investigated its aetiopathogenetic factors, few works have focused on its genetic predisposition and most of them took into account only candidate genes. Therefore, we conducted a Genome Wide Association Study in an Italian isolated population aimed at uncovering genetic variants that predispose to this disorder.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Diagnosis of chronic periodontitis was made following the criteria of the American Academy of Periodontology. Patients with chronic periodontitis were grouped into different categories: slight, severe, localized and generalized. A control group composed by people without signs of periodontitis or gingivitis was defined. <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> was genotyped using 370k Illumina chips. Linear mixed model regression was used to test the association between each single nucleotide polymorphism (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>) (independent variable) and the periodontitis status (dependent variable), controlling for confounders sex, age and smoking. The genomic kinship matrix was also used as random effect.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s on the gene <jats:styled-content style=\"fixed-case\">EFCAB<\/jats:styled-content>4B resulted significantly associated to localized periodontitis (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a05\u00a0\u00d7\u00a010<jats:sup>\u22128<\/jats:sup>), with the best hit on the rs242016 <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0=\u00a01.5\u00a0\u00d7\u00a010<jats:sup>\u22128<\/jats:sup>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We have identified a novel significant association between the <jats:styled-content style=\"fixed-case\">EFCAB<\/jats:styled-content>4B gene and localized periodontitis. These results open a new perspective in the understanding of genetic factors contributing to this common disorder.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12598","type":"journal-article","created":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T21:00:30Z","timestamp":1538773230000},"page":"992-998","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["A genome\u2010wide association study identifies an association between variants in <scp>EFCAB<\/scp>4B gene and periodontal disease in an Italian isolated population"],"prefix":"10.1111","volume":"53","author":[{"given":"Lorenzo","family":"Bevilacqua","sequence":"first","affiliation":[{"name":"Department of Medical Sciences University of Trieste  Trieste Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6697-974X","authenticated-orcid":false,"given":"Chiara O.","family":"Navarra","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences University of Trieste  Trieste Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Pirastu","sequence":"additional","affiliation":[{"name":"Centre for Global Health Research Usher Institute of Population Health Sciences and Informatics University of Edinburgh  Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto Di","family":"Lenarda","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences University of Trieste  Trieste Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Gasparini","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences University of Trieste  Trieste Italy"},{"name":"Institute for Maternal and Child Health\u2014IRCCS \u201cBurlo Garofolo\u201d  Trieste Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonietta","family":"Robino","sequence":"additional","affiliation":[{"name":"Institute for Maternal and Child Health\u2014IRCCS \u201cBurlo Garofolo\u201d  Trieste Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,4]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Web site. 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