{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T12:17:01Z","timestamp":1769602621828,"version":"3.49.0"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,10,4]],"date-time":"2018-10-04T00:00:00Z","timestamp":1538611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["BEX\u20107715\/15\u20103"],"award-info":[{"award-number":["BEX\u20107715\/15\u20103"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Periodontitis is a common oral disease caused by host inflammatory response towards bacteria biofilm. The chronic activation of immune response leads to destruction of teeth supporting tissue, bone loss and tooth detachment. Different factors could be involved in the development and severity of the disease; among them the host genetic background should be considered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>In our study, we analysed haploblocks in a genomic region within major histocompatibility complex (<jats:styled-content style=\"fixed-case\">MHC<\/jats:styled-content>) locus aimed at disclosing a possible correlation with the risk of periodontal disease in 602 adult subjects from North\u2010East Italy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">CTTAC<\/jats:styled-content> haploblock (formed by <jats:italic><jats:styled-content style=\"fixed-case\">LTA<\/jats:styled-content><\/jats:italic>\u2010rs2857709, <jats:italic><jats:styled-content style=\"fixed-case\">LTA<\/jats:styled-content><\/jats:italic>\u2010rs2844484, <jats:italic><jats:styled-content style=\"fixed-case\">LTA<\/jats:styled-content><\/jats:italic>\u2010 rs2229094, <jats:italic><jats:styled-content style=\"fixed-case\">LTA<\/jats:styled-content><\/jats:italic>\u2010rs2229092 and <jats:italic><jats:styled-content style=\"fixed-case\">LTA<\/jats:styled-content><\/jats:italic>\u2010rs1041981 polymorphisms) correlated with protection towards periodontitis condition, after regression analysis including age and smoking status as covariates (<jats:italic>P<\/jats:italic>\u2010value = 0.015).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggest that a haplotype within <jats:italic><jats:styled-content style=\"fixed-case\">LTA<\/jats:styled-content><\/jats:italic> gene (encoding for lymphotoxin alpha) is involved in the susceptibility towards chronic periodontitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12609","type":"journal-article","created":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T20:57:59Z","timestamp":1538773079000},"page":"128-133","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Association of <i><scp>LTA<\/scp><\/i> gene haploblock with periodontal disease in Italian adults"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5886-9129","authenticated-orcid":false,"given":"Luisa","family":"Zupin","sequence":"first","affiliation":[{"name":"Department of Medical Sciences University of Trieste  Trieste Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald","family":"Moura Rodrigues","sequence":"additional","affiliation":[{"name":"Department of Genetics Federal University of Pernambuco  Recife 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