{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:39:59Z","timestamp":1747186799718,"version":"3.40.5"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,3,13]],"date-time":"2019-03-13T00:00:00Z","timestamp":1552435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>The aim of this interventional, parallel\u2010assignment, single\u2010blinded, randomized, efficacy study was to investigate the efficacy of the treatment of gingival recessions by osteogenic cell transfer. This is the first randomized clinical trial of this nature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Treatment of Miller class I or <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> gingival recessions &gt;4\u00a0mm was randomly defined by casual sorting and performed by newly forming bone graft (<jats:styled-content style=\"fixed-case\">NFBG<\/jats:styled-content>) and coronally advanced flap (<jats:styled-content style=\"fixed-case\">CAF<\/jats:styled-content>) or subepithelial connective tissue graft (<jats:styled-content style=\"fixed-case\">SCTG<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">CAF<\/jats:styled-content> (control). Clinical examinations were performed by a single blinded examiner at baseline and at 3, 6, and 9\u00a0months after surgery. Parameters investigated were recession height (<jats:styled-content style=\"fixed-case\">REC<\/jats:styled-content>), probing depth (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>), clinical attachment level, gingival bleeding index (<jats:styled-content style=\"fixed-case\">GBI<\/jats:styled-content>), plaque index (PlI), and keratinized gingiva width (<jats:styled-content style=\"fixed-case\">KGW<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both techniques achieved similar percentage of root coverage, but <jats:styled-content style=\"fixed-case\">NFBG<\/jats:styled-content> was more effective in pocket depth reduction, attachment level gain, and reduction of plaque accumulation and of bleeding on probing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings suggest that the transfer of osteogenic cells by <jats:styled-content style=\"fixed-case\">NFBG<\/jats:styled-content> is able to improve clinical attachment level and to cover denuded roots. <jats:styled-content style=\"fixed-case\">NFBG<\/jats:styled-content> can be used as an alternative treatment of deep recessions (\u22654\u00a0mm), where the restoration of lost periodontal tissues is intended.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12651","type":"journal-article","created":{"date-parts":[[2019,3,13]],"date-time":"2019-03-13T15:22:22Z","timestamp":1552490542000},"page":"506-512","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Osteogenic cells transfer improving root coverage: A randomized clinical trial"],"prefix":"10.1111","volume":"54","author":[{"given":"Bruna F. 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