{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:13:00Z","timestamp":1787015580539,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,4,29]],"date-time":"2019-04-29T00:00:00Z","timestamp":1556496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>The Objective<\/jats:title>\n                    <jats:p>The present study aimed to evaluate the effects of oleuropein on ligature\u2010induced alveolar bone loss. In this respect, osteoblastic activity, osteoclastic activity, inflammatory markers, and apoptosis were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Oleuropein is a flavonoid, which has potent anti\u2010inflammatory and bone\u2010protective effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010two Wistar rats were divided into four experimental groups as following: control (C, n\u00a0=\u00a08) group; periodontitis (P, n\u00a0=\u00a08) group; periodontitis and low\u2010dose oleuropein group (12\u00a0mg\/kg\/day oleuropein,\n                      <jats:styled-content style=\"fixed-case\">LDO<\/jats:styled-content>\n                      group, n\u00a0=\u00a08); and periodontitis and high\u2010dose oleuropein group (24\u00a0mg\/kg\/day oleuropein,\n                      <jats:styled-content style=\"fixed-case\">HDO<\/jats:styled-content>\n                      group, n\u00a0=\u00a08). Periodontitis was induced via ligatures. Study period was 14\u00a0days, and animals were sacrificed at end of this period. Mandibles were examined via a stereomicroscope and underwent histological procedures. Osteoblast, tartrate\u2010resistant acid phosphatase (\n                      <jats:styled-content style=\"fixed-case\">TRAP<\/jats:styled-content>\n                      )\u2010positive osteoclast, and inflammatory cell counts were determined in hematoxylin\u2010eosin stained sections. Inducible nitric oxide synthase (\n                      <jats:styled-content style=\"fixed-case\">iNOS<\/jats:styled-content>\n                      ), bone morphogenetic protein\u20104, the cluster of differentiation (\n                      <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                      )\u201068, cysteine\u2010aspartic proteases\u20103 (Caspase 3), and B\u2010cell lymphoma\u20102 (Bcl\u20102) expressions were evaluated via immunohistochemistry.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Periodontitis group had highest alveolar bone loss, and these levels significantly decreased in\n                      <jats:styled-content style=\"fixed-case\">LDO<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">HDO<\/jats:styled-content>\n                      groups. Both 12 and 24\u00a0mg\/kg oleuropein groups significantly increased osteoblast cell counts and decreased\n                      <jats:styled-content style=\"fixed-case\">TRAP<\/jats:styled-content>\n                      \u2010positive osteoclast and inflammatory cell counts.\n                      <jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\n                      \u20104 and bcl\u20102 expressions were elevated in oleuropein groups while caspase\u20103 expressions decreased.\n                      <jats:styled-content style=\"fixed-case\">iNOS<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                      68 were higher in periodontitis group compared to control group, but there was no significant difference between other groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Oleuropein successfully decreased alveolar bone loss as a result of decreased osteoclastic activity, inflammation, and apoptosis and increased osteoblastic activity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jre.12662","type":"journal-article","created":{"date-parts":[[2019,4,29]],"date-time":"2019-04-29T07:17:31Z","timestamp":1556522251000},"page":"624-632","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Evaluation of the effect of oleuropein on alveolar bone loss, inflammation, and apoptosis in experimental periodontitis"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4830-0075","authenticated-orcid":false,"given":"Mehmet Murat","family":"Taskan","sequence":"first","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Tokat Gaziosmanpasa University Tokat 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