{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T04:31:39Z","timestamp":1770697899338,"version":"3.49.0"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,7,10]],"date-time":"2019-07-10T00:00:00Z","timestamp":1562716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>Full\u2010mouth scaling and root planing (FM\u2010SRP) increases the systemic levels of inflammatory mediators via early inflammation but may be inhibited using an antimicrobial agent. This prospective intervention study evaluates the biological response and clinical effects of FM\u2010SRP with and without systemically administered azithromycin (AZM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A multicenter parallel randomized controlled and open\u2010label trial. A central randomization center used computer\u2010generated tables to allocate treatments. Sixty\u2010three patients with moderate to severe generalized periodontitis (New American Academy of Periodontology Classification: Stage3 or 4, Grade B) were randomly assigned to receive FM\u2010SRP with AZM (test group, n\u00a0=\u00a032) or FM\u2010SRP without AZM (control group, n\u00a0=\u00a031). Clinical parameters and body temperature were measured, and subgingival plaque, peripheral blood, and gingival crevicular fluid were collected before and after treatment. Periodontopathic bacteria and IgG titers were measured by gingival crevicular fluid and peripheral blood. High\u2010sensitivity assays were used to analyze systemic and local inflammatory markers, such as endotoxin, high\u2010sensitive CRP (hs\u2010CRP), and six inflammatory cytokines. Follow\u2010up 6\u00a0weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The total number of bacteria and the number of <jats:italic>Porphyromonas gingivalis<\/jats:italic> and <jats:italic>Prevotella intermedia<\/jats:italic> were significantly lower in the test group after FM\u2010SRP. IgG titers for <jats:italic>P\u00a0gingivalis<\/jats:italic> significantly decreased after FM\u2010SRP with AZM, and the body temperature increased significantly after FM\u2010SRP without AZM. In the control group, serum hs\u2010CRP, IFN\u2010\u03b3, IL\u201012p70, and IL\u20106 were significantly increased one day after treatment, but subsequently decreased below the original numerical value. In the test group, only hs\u2010CRP showed a significant increase.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>FM\u2010SRP resulted in similar improvements in clinical parameters with and without the use of AZM. Inflammatory mediators showed no difference between the two groups after FM\u2010SRP treatment. The use of AZM was effective in preventing the elevation of body temperature after FM\u2010SRP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12680","type":"journal-article","created":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T05:05:27Z","timestamp":1562821527000},"page":"709-719","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Biological responses following one\u2010stage full\u2010mouth scaling and root planing with and without azithromycin: Multicenter randomized trial"],"prefix":"10.1111","volume":"54","author":[{"given":"Akihiro","family":"Yashima","sequence":"first","affiliation":[{"name":"Department of Periodontology, School of Dental Medicine Tsurumi University Yokohama 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