{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T13:28:32Z","timestamp":1782307712750,"version":"3.54.5"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,7,10]],"date-time":"2019-07-10T00:00:00Z","timestamp":1562716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["R01DE019456"],"award-info":[{"award-number":["R01DE019456"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The purpose of this study was to investigate involvement of the P2X7 receptor in the rare condition, localized aggressive periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Peripheral blood from 220 African Americans (103 with localized aggressive periodontitis and 117 healthy unrelated controls) was stimulated with lipopolysaccharide from <jats:italic>E<\/jats:italic>\u00a0<jats:italic>coli<\/jats:italic> and <jats:italic>Porphyromonas gingivalis<\/jats:italic>. <jats:italic>P2RX7<\/jats:italic> single nucleotide polymorphisms rs208294 (H155Y), rs1718119 (T348A), rs2230911 (T357S) and rs3751143 (E496A) were genotyped in 103 localized aggressive periodontitis patients and 117 healthy unrelated subjects. We examined genetic association between four <jats:italic>P2RX7<\/jats:italic> single nucleotide polymorphisms and localized aggressive periodontitis, and tested for correlations between the single nucleotide polymorphisms and inflammatory response to lipopolysaccharide in blood samples from these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A significant association with localized aggressive periodontitis was observed with rs1718119 A (Thr) allele (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0063, odds ratio\u00a0=\u00a01.904) and with a haplotype containing this allele (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0075). Additionally, significant correlations with these data were found: the rs1718119 G allele correlated with greater production of IL\u20106, IL\u20102 and GM\u2010CSF; the C (His) allele of rs208294 correlated with lower levels of IL\u201012p40; and the C (Thr) allele of rs2230911 correlated with greater levels of G\u2010CSF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The data from these analyses support a possible biological relationship between <jats:italic>P2RX7<\/jats:italic> genetic variants and inflammatory response in localized aggressive periodontitis patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12682","type":"journal-article","created":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T05:01:01Z","timestamp":1562821261000},"page":"32-40","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Association of <i>P2RX7<\/i> functional variants with localized aggressive periodontitis"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6589-9764","authenticated-orcid":false,"given":"Theodore H.","family":"Harris","sequence":"first","affiliation":[{"name":"Department of Periodontology University of Florida College of Dentistry Gainesville Florida USA"},{"name":"Department of Oral Biology University of Florida College of Dentistry Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret R.","family":"Wallace","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Microbiology University of Florida College of Medicine Gainesville Florida USA"},{"name":"University of Florida Genetics Institute Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Periodontology University of Florida College of Dentistry Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Microbiology University of Florida College of Medicine Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azeem","family":"Mohiuddeen","sequence":"additional","affiliation":[{"name":"Department of Periodontology University of Florida College of Dentistry Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics University of Florida College of Pharmacy Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodora","family":"Kompotiati","sequence":"additional","affiliation":[{"name":"Department of Periodontology University of Florida College of Dentistry 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