{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:05:51Z","timestamp":1780445151827,"version":"3.54.1"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,12,5]],"date-time":"2019-12-05T00:00:00Z","timestamp":1575504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>The study compared clinical and patient\u2010centered outcomes of subepithelial connective tissue graft (CTG) with and without enamel matrix derivative (EMD) in the treatment of Class I\u2010II Miller periodontal recession defects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>This prospective clinical study evaluated 80 patients over a 3\u00a0years follow\u2010up in a private periodontal practice. A total of 144 maxillary and mandibular anterior teeth were divided into two groups: group 1 (CTG with EMD\u201480 teeth) and group 2 (CTG only\u201464 teeth). Recession (REC), keratinized tissue (KT) width, % root overage, patient\u2010centered outcomes, and pain visual analog scale (P\u2010VAS) were compared between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 3\u00a0years follow\u2010up at a patient level, statistically significant changes in REC were achieved in both group 1 (4.65\u00a0\u00b1\u00a01.84 to 0.39\u00a0\u00b1\u00a00.19\u00a0mm) and group 2 (4.43\u00a0\u00b1\u00a01.11 to 0.92\u00a0\u00b1\u00a00.43\u00a0mm). Complete root coverage (CRC) was achieved in 66.4% of group 1 and 50.1% of group 2. At both patient and tooth level, the 3\u2010year outcomes were superior for group 1 compared with group 2 in terms of % root coverage, REC, and KT width. Clinical attachment loss (CAL) was reduced in group 1 compared with group 2 at the tooth level analysis only (&lt;.01). Significantly less pain was reported using the pain visual analog Scale (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) at the two weeks follow\u2010up post\u2010surgery in group 1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Addition of EMD results in improved root coverage outcomes and higher amounts of keratinized tissue width 36\u00a0months after treatment of multiple adjacent recessions on maxillary and mandibular anterior teeth. The adjunctive use of EMD also resulted in significantly reduced pain 14\u00a0days after the surgery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12715","type":"journal-article","created":{"date-parts":[[2019,12,6]],"date-time":"2019-12-06T04:33:20Z","timestamp":1575606800000},"page":"296-306","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["A 3\u2010year prospective clinical and patient\u2010centered trial on subepithelial connective tissue graft with or without enamel matrix derivative in Class I\u2010II Miller recessions"],"prefix":"10.1111","volume":"55","author":[{"given":"Faustino","family":"Mercado","sequence":"first","affiliation":[{"name":"School of Dentistry and Oral Health Griffith University Gold Coast Qld Australia"},{"name":"School of Dentistry University of Queensland Brisbane Qld Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1283-3395","authenticated-orcid":false,"given":"Stephen","family":"Hamlet","sequence":"additional","affiliation":[{"name":"School of Dentistry and Oral Health Griffith University Gold Coast Qld Australia"},{"name":"Menzies Health Institute Queensland Griffith University Gold Coast Qld Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5339-0936","authenticated-orcid":false,"given":"Sa\u0161o","family":"Ivanovski","sequence":"additional","affiliation":[{"name":"School of Dentistry University of Queensland Brisbane Qld Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1996.1.1.702"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.10.1377"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100102"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.20"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.5.762"},{"issue":"71","key":"e_1_2_7_7_1","first-page":"228","article-title":"Management and prevention of gingival recession","volume":"2006","author":"Merjohn GK","journal-title":"Periodontol 2000"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910408300810"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.050450"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.4.600"},{"key":"e_1_2_7_11_1","first-page":"3","article-title":"Histological evaluation of human gingival recession treated with subepithelial connective tissue graft plus enamel matrix derivative. 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