{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T11:20:58Z","timestamp":1787224858239,"version":"build-2736575974"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T00:00:00Z","timestamp":1583798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Scientific Research Projects of Selcuk University","award":["SELCUK\/BAP-14102025"],"award-info":[{"award-number":["SELCUK\/BAP-14102025"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective and Background<\/jats:title><jats:p>Developmental endothelial locus\u20101 (Del\u20101), lymphocyte function\u2010associated antigen\u20101 (LFA\u20101), and interleukin 17 (IL\u201017) play critical roles in transendothelial migration of neutrophils in periodontal diseases. The aim of this study was to evaluate salivary Del\u20101, IL\u201017, and LFA\u20101 protein levels in patients with gingivitis (G), chronic periodontitis (CP), and generalized aggressive periodontitis (GAP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 180 systemically healthy, non\u2010smoking patients (45 periodontally healthy (H) and 45 G, 50 CP, and 40 GAP) individuals (between March 2014 and February 2016) were included in this study according to Armitage's (1999) classification. Clinical periodontal parameters, including clinical attachment level, probing depth, plaque index, and gingival index, were recorded. Del\u20101, IL\u201017, and LFA\u20101 protein expression levels were measured in unstimulated saliva samples collected from patients by using enzyme\u2010linked immunosorbent assays. <jats:italic>Kruskal\u2010Wallis<\/jats:italic> and <jats:italic>Mann\u2010Whitney U tests<\/jats:italic> were used for multiple comparisons and post hoc statistical analyses, respectively. ROC curve analysis was used to evaluate the sensitivity and specificity of Del\u20101, IL\u201017, and LFA\u20101 in distinguishing periodontal disease from health and gingivitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>It was found a high level of IL\u201017 and a low level of Del\u20101 in the CP and GAP, as compared to the G and H groups (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). Nevertheless, we found LFA\u20101 levels were higher in the GAP than in the CP or G groups (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.00). Consistently, LFA\u20101 levels were lower in the H and G groups than in the CP and GAP groups (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.00). The combination of three biomarkers was found as the best predictor yielded exhibited the highest AUC [0.893, 0.845\u20100.94 (%95 CI) <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001] in discriminating periodontal disease from health and gingivitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Salivary Del\u20101, LFA\u20101, and IL\u201017 levels might be useful markers for determining the clinical health and disease status of patients with periodontitis. However, further studies that evaluate the level of salivary Del\u20101, LFA\u20101, and IL\u201017 before and after periodontal therapy are required to understand the exact roles of these cytokines during the periodontal healing period.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12738","type":"journal-article","created":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T08:34:42Z","timestamp":1583829282000},"page":"511-518","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Salivary Del\u20101, IL\u201017, and LFA\u20101 levels in periodontal health and disease"],"prefix":"10.1111","volume":"55","author":[{"given":"Elif","family":"In\u00f6n\u00fc","sequence":"first","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Baskent University Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyit Ali","family":"Kayis","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Faculty of Medicine Karabuk University Karabuk Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Akif","family":"Eskan","sequence":"additional","affiliation":[{"name":"Department of Periodontics NOVA Southeastern University College of Dental Medicine Fort Lauderdale FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sema S.","family":"Hakki","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Selcuk University Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0188945"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2013.130092"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1590\/1678-775720140259"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2156"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2260"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2016.02.002"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/617809"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aac5380"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2014.146"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12117"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1384.028"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.5005\/jcdp-9-3-72"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034510380414"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jobcr.2015.08.006"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12100"},{"issue":"4","key":"e_1_2_8_17_1","first-page":"95","article-title":"Oral fluid based biomarkers in periodontal disease: part 1","volume":"6","author":"AlMoharib HS","year":"2014","journal-title":"Saliva. 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