{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:32:19Z","timestamp":1790728339819,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T00:00:00Z","timestamp":1584316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004505","name":"Universit\u00e0 di Catania","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004505","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>Vitamin D has been considered to possess anti\u2010inflammatory and antimicrobial activity, which may be a link for the known interaction of periodontitis (CP) and coronary heart disease (CHD). This study investigated the association between serum vitamin D levels and periodontitis in patients with CP and with CHD. Furthermore, the objective was to determine whether periodontitis and CHD had an impact on serum vitamin D levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Using a cross\u2010sectional design, a total of 46 patients with CP, 45 patients with CHD, 45 patients with both CP and CHD, and 43 healthy patients were enrolled in the present study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients in the CP (17.4\u00a0\u00b1\u00a05.2\u00a0ng\/mL) and in the CP\u00a0+\u00a0CHD (16.5\u00a0\u00b1\u00a05.6\u00a0ng\/mL) group presented a significantly lower mean serum level of 25(OH)vitamin D compared to patients in the CHD (24.6\u00a0\u00b1\u00a03.7\u00a0ng\/mL) and healthy control groups (29.9\u00a0\u00b1\u00a05.4\u00a0ng\/mL) (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). 25(OH)vitamin D levels were positively correlated with the number of teeth and negatively with C\u2010reactive protein (CRP) and all periodontal parameters (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). In all patients, there was a proportional increase of 25(OH)vitamin D levels with a progressive increase in number of teeth (<jats:italic>P<\/jats:italic>\u2010trend &lt;.001) while there were a proportional decrease in 25(OH)vitamin D levels with a progressive increase in clinical attachment level (CAL,<jats:italic>P<\/jats:italic>\u2010trend\u00a0=\u00a0.001), probing depth (PD,<jats:italic>P<\/jats:italic>\u2010trend\u00a0=\u00a0.006), and bleeding sites (BOP,<jats:italic>P<\/jats:italic>\u2010trend &lt;.001) levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with CP and CP\u00a0+\u00a0CHD presented significantly lower serum levels of vitamin D compared to CHD and healthy controls. Moreover, the presence of CP negatively influenced serum vitamin D levels.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12746","type":"journal-article","created":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T08:55:32Z","timestamp":1584348932000},"page":"602-612","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":97,"title":["Association of vitamin D in patients with periodontitis: A cross\u2010sectional study"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4267-6992","authenticated-orcid":false,"given":"Gaetano","family":"Isola","sequence":"first","affiliation":[{"name":"Department of General Surgery and Surgical\u2010Medical Specialties University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Alibrandi","sequence":"additional","affiliation":[{"name":"Department of Economical, Business and Environmental Sciences and 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