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These are imprecise and are somewhat invasive. There is thus significant benefit to creating a non\u2010invasive test as a method of screening for and monitoring of periodontal diseases, and, in particular, chronic periodontitis. Oral polymorphonuclear neutrophil (oPMN) counts have been found to correlate with extent of oral inflammation and the presence and severity of periodontal diseases. Potentially then, quantification of oPMNs might be used to identify and measure the severity of oral inflammation (oral inflammatory load; OIL) in subjects with healthy and inflamed periodontal tissues, demonstrating a positive correlation between higher oPMN counts and the extent\/severity of OIL. These findings support the development and utilization of a non\u2010invasive chair\u2010side test enabling rapid, accurate, and objective screening of OIL based on measurement of oPMN numbers (similar to white blood cell levels in blood as used in medicine for assessment of infection). The use of such a test before, during, and after treatment of gingivitis and periodontitis could lead to improvements in timing of intervention (ie, when inflammation is active) thereby reducing long\u2010term morbidity.<\/jats:p>","DOI":"10.1111\/jre.12758","type":"journal-article","created":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T08:39:41Z","timestamp":1588754381000},"page":"594-601","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Oral inflammatory load: Neutrophils as oral health biomarkers"],"prefix":"10.1111","volume":"55","author":[{"given":"William","family":"Khoury","sequence":"first","affiliation":[{"name":"Faculty of Dentistry University of Toronto Toronto ON Canada"},{"name":"Queen\u2019s University School of Medicine Kingston ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judah","family":"Glogauer","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry University of Toronto Toronto ON Canada"},{"name":"Michael G. 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