{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:39:53Z","timestamp":1790775593965,"version":"4.1.0"},"reference-count":132,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,6,20]],"date-time":"2020-06-20T00:00:00Z","timestamp":1592611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Alumni Endowment Fund, University of Tennessee Health Science Center, Tennessee Dental Association Foundation, College of Dentistry, University of Tennessee Health Science Center","award":["Alumni Endowment Fund"],"award-info":[{"award-number":["Alumni Endowment Fund"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study is to understand the role of cannabinoid type 2 receptor (CB2R) during periodontal inflammation and to identify anti\u2010inflammatory agents for the development of drugs to treat periodontitis (PD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Cannabinoid type 2 receptor is found in periodontal tissue at sites of inflammation\/infection. Our previous study demonstrated anti\u2010inflammatory responses in human periodontal ligament fibroblasts (hPDLFs) via CB2R ligands.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Anandamide (AEA), HU\u2010308 (agonist), and SMM\u2010189 (inverse agonist) were tested for effects on IL\u20101\u03b2\u2010stimulated cytokines, chemokines, and angiogenic and vascular markers expressed by hPDLFs using Mesoscale Discovery V\u2010Plex Kits. Signal transduction pathways (p\u2010c\u2010Jun, p\u2010ERK, p\u2010p\u201038, p\u2010JNK, p\u2010CREB, and p\u2010NF\u2010kB) were investigated using Cisbio HTRF kits. ACTOne and Tango\u2122 \u2010BLA functional assays were used to measure cyclic AMP (cAMP) and \u03b2\u2010arrestin activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>IL\u20101\u03b2 stimulated hPDLF production of 18\/39 analytes, which were downregulated by the CB2R agonist and the inverse agonist. AEA exhibited pro\u2010inflammatory and anti\u2010inflammatory effects. IL\u20101\u03b2 increased phosphoproteins within the first hour except p\u2010JNK. CB2R ligands attenuated p\u2010p38 and p\u2010NF\u0138B, but a late rise in p\u201038 was seen with HU\u2010308. As p\u2010ERK levels declined, a significant increase in p\u2010ERK was observed later in the time course by synthetic CB2R ligands. P\u2010JNK was significantly affected by SMM\u2010189 only, while p\u2010CREB was elevated significantly by CB2R ligands at 180\u00a0minutes. HU\u2010308 affected both cAMP and \u03b2\u2010arrestin pathway. SMM\u2010189 only stimulated cAMP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The findings that CB2R agonist and inverse agonist may potentially regulate inflammation suggest that development of CB2R therapeutics could improve on current treatments for PD and other oral inflammatory pathologies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12765","type":"journal-article","created":{"date-parts":[[2020,6,20]],"date-time":"2020-06-20T07:57:46Z","timestamp":1592639866000},"page":"762-783","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Cannabinoid type\u20102 receptor agonist, inverse agonist, and anandamide regulation of inflammatory responses in IL\u20101\u03b2 stimulated primary human periodontal ligament fibroblasts"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1826-9377","authenticated-orcid":false,"given":"Ammaar H.","family":"Abidi","sequence":"first","affiliation":[{"name":"College of Dentistry The University of Tennessee Health Science Center Memphis TN USA"},{"name":"Department of Bioscience Research The University of Tennessee Health Science Center Memphis TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar S.","family":"Alghamdi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences The University of Tennessee Health Science Center Memphis TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa Kh.","family":"Dabbous","sequence":"additional","affiliation":[{"name":"College of Dentistry The University of Tennessee Health Science Center Memphis TN USA"},{"name":"Department of Bioscience Research The University of Tennessee Health Science Center Memphis TN USA"},{"name":"College of Medicine The University of Tennessee Health Science Center Memphis TN USA"},{"name":"Department of Microbiology, Immunology and Biochemistry The University of Tennessee Health Science Center Memphis TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6999-5315","authenticated-orcid":false,"given":"David A.","family":"Tipton","sequence":"additional","affiliation":[{"name":"College of Dentistry The University of Tennessee Health Science Center Memphis TN USA"},{"name":"Department of Bioscience Research The University of Tennessee Health Science Center Memphis TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suni M.","family":"Mustafa","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences The University of Tennessee Health Science Center Memphis TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6766-4264","authenticated-orcid":false,"given":"Bob M.","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences The University of Tennessee Health Science Center Memphis TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034514552491"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2002.290111.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67728-8"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb01187.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1996.67.10s.1041"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1994.65.3.260"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1992.63.4s.338"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1999.tb00162.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.61.2.602-609.1993"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1993.tb00348.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1994.tb00074.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.64.11.4450-4455.1996"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1998.69.10.1139"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1995.66.10.852"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2041-1014.2011.00609.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12002"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1984.tb00903.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1981.tb00953.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1983.tb02201.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2009.11.005"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2005.04.023"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/apha.12474"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0303101"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2005.12.079"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1995.tb20780.x"},{"issue":"3","key":"e_1_2_8_27_1","first-page":"443","article-title":"Comparison of the pharmacology and signal transduction of the human cannabinoid cb1 and cb2 receptors","volume":"48","author":"Felder CC","year":"1995","journal-title":"Mol Pharmacol"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2009.01.005"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1602"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.03.080"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm4005626"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2017.12.005"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1997.tb00094.x"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100054"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2010.01331.x"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/prp2.159"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1003470"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1462399409000957"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2012.11.024"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2014.07.005"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2016.00449"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.116.232561"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.25.14228"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13958"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12164"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2011.100472"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2013.1222"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910708600409"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.61.12.5219-5224.1993"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1994.65.2.147"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cr.7310017"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2003.00350.x"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1100\/2012\/756357"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvp241"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.10.1535"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.job.2012.02.001"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1998.tb02349.x"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.070009"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.5125\/jkaoms.2015.41.1.11"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1999.79.1.181"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2006.03064.x"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2003.00372.x"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1998.tb02517.x"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-013-9766-0"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/438085"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2013.130152"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1995.tb01268.x"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.17.4.2845"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(98)00575-5"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.163.3.1602"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2017.160679"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-007-7499-7"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sdentj.2018.07.002"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.2002.1985"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080287"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S177188"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1991.tb01729.x"},{"key":"e_1_2_8_78_1","article-title":"Expression of interleukin (il)\u20101\u03b2, il\u20108, il\u201010 and il\u201013 in chronic adult periodontitis progression","volume":"9","author":"T\u00e2lvan ETMC","year":"2017","journal-title":"Archives Med"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-018-0481-y"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.114702"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2007.01080.x"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/7806912"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199910)29:10<3210::AID-IMMU3210>3.0.CO;2-W"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI12655"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.118.2.503"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/22761"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0707460"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11481-012-9351-6"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01497.x"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705467"},{"issue":"1","key":"e_1_2_8_91_1","first-page":"7","article-title":"effects of anandamide on il\u201011 production through the trpv1 of human periodontal ligament cells","volume":"79","author":"Haruta C","year":"2012","journal-title":"Kokubyo Gakkai Zasshi"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13497"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2005.05.032"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2014.12.014"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004770-200203000-00012"},{"issue":"1","key":"e_1_2_8_96_1","first-page":"219","article-title":"Peroxisome proliferator\u2010activated receptor\u2010\u03b3 and its related pathway in bone marrow mesenchymal stem cell differentiation co\u2010cultured with mechanically stretched ligament fibroblasts","volume":"42","author":"Zhao B","year":"2018","journal-title":"Int J Mol Med"},{"key":"e_1_2_8_97_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.24.7033"},{"key":"e_1_2_8_98_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016357.2011.645067"},{"key":"e_1_2_8_99_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.1.47"},{"key":"e_1_2_8_100_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11626-011-9388-5"},{"key":"e_1_2_8_101_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14521"},{"key":"e_1_2_8_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2005.12.079"},{"key":"e_1_2_8_103_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0107407"},{"key":"e_1_2_8_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41368-019-0064-z"},{"key":"e_1_2_8_105_1","doi-asserted-by":"publisher","DOI":"10.4236\/ojst.2013.31009"},{"key":"e_1_2_8_106_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V80.11.2920.2920"},{"key":"e_1_2_8_107_1","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb\/7.5.507"},{"key":"e_1_2_8_108_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1992.tb00057.x"},{"key":"e_1_2_8_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.10.026"},{"key":"e_1_2_8_110_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01328.2007"},{"key":"e_1_2_8_111_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01673.x"},{"key":"e_1_2_8_112_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.228"},{"key":"e_1_2_8_113_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1462399409000957"},{"key":"e_1_2_8_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2012.12.012"},{"key":"e_1_2_8_115_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1995.66.1.80"},{"key":"e_1_2_8_116_1","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.2002.1985"},{"key":"e_1_2_8_117_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ket447"},{"key":"e_1_2_8_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1567-5769(03)00163-2"},{"key":"e_1_2_8_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.03.080"},{"key":"e_1_2_8_120_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01328.2007"},{"key":"e_1_2_8_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2008.09.014"},{"key":"e_1_2_8_122_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20907"},{"key":"e_1_2_8_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2018.e00909"},{"key":"e_1_2_8_124_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-16524-w"},{"key":"e_1_2_8_125_1","doi-asserted-by":"publisher","DOI":"10.1590\/1678-7757-2017-0231"},{"key":"e_1_2_8_126_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.4.974"},{"key":"e_1_2_8_127_1","doi-asserted-by":"publisher","DOI":"10.1159\/000057320"},{"key":"e_1_2_8_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2005.08.007"},{"key":"e_1_2_8_129_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111718200"},{"key":"e_1_2_8_130_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2001.0502"},{"key":"e_1_2_8_131_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07039"},{"key":"e_1_2_8_132_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M301942200"},{"key":"e_1_2_8_133_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2016.150713"}],"container-title":["Journal of Periodontal Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjre.12765","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jre.12765","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jre.12765","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jre.12765","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T18:34:41Z","timestamp":1693938881000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jre.12765"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,20]]},"references-count":132,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1111\/jre.12765"],"URL":"https:\/\/doi.org\/10.1111\/jre.12765","archive":["Portico"],"relation":{},"ISSN":["0022-3484","1600-0765"],"issn-type":[{"value":"0022-3484","type":"print"},{"value":"1600-0765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,20]]},"assertion":[{"value":"2019-08-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}