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Matrix metalloproteinase (MMP)\u20108 is the major collagenase of periodontal tissue breakdown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Totally 83 systemically healthy and non\u2010smoker individuals consisting of 23 periodontally healthy, 20 gingivitis and 40 stage 3 periodontitis, were recruited to the study. Clinical periodontal examinations of probing depth (PD), clinical attachment loss (CAL), gingival index (GI), plaque index (PI) and bleeding on probing (BOP) were recorded; and GCF, saliva and serum samples were obtained. aMMP\u20108 was measured by immunofluorometric assay (IFMA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>GCF and serum aMMP\u20108 levels were significantly increased in periodontitis and gingivitis compared to healthy ones (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), whereas gingivitis and periodontitis patients showed similar levels of aMMP\u20108 in GCF and serum (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a0.05). Saliva levels of aMMP\u20108 were higher in periodontitis patients than both gingivitis and healthy individuals (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). There was no significant difference in salivary aMMP\u20108 levels between gingivitis group and healthy controls (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings support the involvement of aMMP\u20108 in periodontal diseases and suggest that its local and systemic levels can reflect stage 3 grade C periodontitis. Moreover, aMMP\u20108 in GCF and serum seems to have a potential to differentiate between gingivitis and periodontal health.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12781","type":"journal-article","created":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T14:31:58Z","timestamp":1597329118000},"page":"887-894","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Local and systemic levels of aMMP\u20108 in gingivitis and stage 3 grade C periodontitis"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9139-8752","authenticated-orcid":false,"given":"Zeynep Pinar","family":"Keles Yucel","sequence":"first","affiliation":[{"name":"Department of Periodontology School of Dentistry Giresun University Giresun Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beral","family":"Afacan","sequence":"additional","affiliation":[{"name":"Department of Periodontology School of 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