{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T07:11:59Z","timestamp":1775545919485,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T00:00:00Z","timestamp":1600214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007619","name":"Osteology Foundation","doi-asserted-by":"publisher","award":["YR\u201015\u2010244"],"award-info":[{"award-number":["YR\u201015\u2010244"]}],"id":[{"id":"10.13039\/501100007619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["4072\u2010B28"],"award-info":[{"award-number":["4072\u2010B28"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of the study was to determine whether the inhibition of apoptosis via pan\u2010caspase inhibitors can attenuate the changes in the alveolar ridge upon tooth extraction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Cells undergoing apoptosis might play a central role in the onset of alveolar bone resorption and the ensuing bone atrophy following tooth extraction. Caspases are proteases that regulate apoptotic cell death. It is, therefore, reasonable to hypothesize that blocking apoptosis with pan\u2010caspase inhibitors attenuates the changes in the alveolar ridge following tooth extraction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 16 inbred rats, the mandibular first (M1) and second (M2) molars of one side were extracted. Following random allocation, the rats received either a cell\u2010permeable pan\u2010caspase inhibitor or diluent. After a healing period of 10\u00a0days, changes in shape and height of the alveolar ridge were examined using geometric morphometrics and linear measurements based on micro\u2010computed tomography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Geometric morphometric analysis revealed that the pan\u2010caspase inhibitor prevented major shape changes of the alveolar ridge following M1 tooth extraction (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). Furthermore, linear measurements confirmed that the pan\u2010caspase inhibitor significantly prevented the atrophy of the alveolar ridge height following M1 tooth extraction compared to the diluent controls (\u22120.53\u00a0mm vs \u22120.24\u00a0mm; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.012). M2 tooth extraction caused no shape changes of the alveolar ridge, and thus, the pan\u2010caspase inhibitor group did not differ from the control group (\u22120.14 mm vs \u22120.05 mm; P = .931).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings suggest that the inhibition of apoptosis may attenuate shape changes of the alveolar ridge following M1 tooth extraction in rodents.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12798","type":"journal-article","created":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T20:45:54Z","timestamp":1600289154000},"page":"101-107","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Caspase inhibitor attenuates the shape changes in the alveolar ridge following tooth extraction: A pilot study in rats"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8954-0024","authenticated-orcid":false,"given":"Uwe Yacine","family":"Schwarze","sequence":"first","affiliation":[{"name":"Department of Oral Biology Medical University of Vienna Vienna Austria"},{"name":"Division of Oral Surgery and Orthodontics Department of Dental Medicine and Oral Health Medical University of Graz Graz Austria"},{"name":"Austrian Cluster for Tissue Regeneration Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5832-7327","authenticated-orcid":false,"given":"Franz\u2010Josef","family":"Strauss","sequence":"additional","affiliation":[{"name":"Clinic of Reconstructive Dentistry Center of Dental Medicine University of Zurich Zurich Switzerland"},{"name":"Department of Conservative Dentistry Faculty of Dentistry University of Chile Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5400-9009","authenticated-orcid":false,"given":"Reinhard","family":"Gruber","sequence":"additional","affiliation":[{"name":"Department of Oral Biology Medical University of Vienna Vienna Austria"},{"name":"Austrian Cluster for Tissue Regeneration Vienna Austria"},{"name":"Department of Periodontology School of Dental Medicine University of Bern Bern 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