{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:37:52Z","timestamp":1747186672001,"version":"3.40.5"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,20]],"date-time":"2020-09-20T00:00:00Z","timestamp":1600560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["H13\u2010Iryo\u2010001"],"award-info":[{"award-number":["H13\u2010Iryo\u2010001"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Few studies have assessed the possible interaction between and impact of <jats:italic>IL\u20106<\/jats:italic> variants and serum \u03b1\u2010tocopherol levels on periodontal condition in older individuals. Here, we assessed the relationship between <jats:italic>IL\u20106<\/jats:italic> variants and serum \u03b1\u2010tocopherol levels on periodontal condition by considering effect modification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Among the study participants, 359 who were 71\u00a0years of age underwent a dental examination, biochemical analysis, and interview. After dividing the participants into tertiles based on serum \u03b1\u2010tocopherol levels, we conducted Poisson regression analysis to compare the prevalence rate ratio (PRR) for periodontal disease markers with the <jats:italic>IL<\/jats:italic>\u20106 genotype (rs1800796) based on each tertile adjusted by the number of teeth present (offset).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The PRRs of the <jats:italic>IL<\/jats:italic>\u20106 genotype for periodontal condition (probing pocket depth [PPD], clinical attachment level [CAL], and bleeding on probing [BOP]) which were adjusted by the number of teeth present (offset) were 1.17 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), 1.37 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), and 1.08 (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.048), respectively. In addition, a significant association was found between the reciprocal number of PRRs of the <jats:italic>IL<\/jats:italic>\u20106 genotype and three serum \u03b1\u2010tocopherol levels. The adjusted PRRs (\u00b1 standard error) of the <jats:italic>IL<\/jats:italic>\u20106 genotypes for PPD were 0.48 (0.12) for the first group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), 1.54 (0.04) for the second group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), and 2.11 (0.03) for the third group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001); similar tendencies were seen for CAL and BOP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results of this study suggest a potential association between the <jats:italic>IL<\/jats:italic>\u20106 genotype and periodontal condition in relation to serum antioxidant concentrations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12802","type":"journal-article","created":{"date-parts":[[2020,9,20]],"date-time":"2020-09-20T08:05:15Z","timestamp":1600589115000},"page":"139-146","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Interaction between and impact of <i>IL\u20106<\/i> genotype and alpha\u2010tocopherol levels on periodontal condition in aging individuals"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0424-8228","authenticated-orcid":false,"given":"Akihiro","family":"Yoshihara","sequence":"first","affiliation":[{"name":"Division of Oral Science for Health Promotion Faculty of Dentistry &amp; Graduate School of Medical and Dental Science Niigata University Niigata 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