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To minimize this, various bone graft materials have been used for alveolar ridge preservation. This study aimed to evaluate additional effects of the concomitant use of recombinant human fibroblast growth factor\u20102 (rhFGF\u20102) with \u03b2\u2010tricalcium phosphate (\u03b2\u2010TCP) on ridge preservation in a dehiscence defect model after tooth extraction in dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>The maxillary first premolars of six beagle dogs were extracted and dehiscence defects of 4\u00a0\u00d7\u00a04\u00a0\u00d7\u00a05\u00a0mm (mesio\u2010distal width\u00a0\u00d7\u00a0bucco\u2010palatal width\u00a0\u00d7\u00a0depth) were created. Bilateral defects were filled with \u03b2\u2010TCP combined with 0.3% (w\/v) rhFGF\u20102 (test sites) or the scaffold alone (control sites). Twelve weeks post\u2010surgery, histologic and histometric evaluations were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Morphological measurements using micro\u2010computed tomography revealed a significantly greater bone volume at the test sites (48.9\u00a0\u00b1\u00a09.06 mm<jats:sup>3<\/jats:sup>) than at the control sites (38.8\u00a0\u00b1\u00a07.24 mm<jats:sup>3<\/jats:sup>). Horizontal widths of the alveolar ridge at the coronal and middle position at the test sites (2.18\u00a0\u00b1\u00a00.71\u00a0mm, 2.93\u00a0\u00b1\u00a00.53\u00a0mm) were significantly greater than those at the control sites (1.47\u00a0\u00b1\u00a00.41\u00a0mm, 2.36\u00a0\u00b1\u00a00.45\u00a0mm, respectively). Regarding the histological parameters, the occupation rate of mineralized bone in the original defects was slightly higher at the test sites (44.07\u00a0\u00b1\u00a010.19%) than that at the control site (41.15\u00a0\u00b1\u00a06.56%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results indicate that the adjunct use of rhFGF\u20102 with \u03b2\u2010TCP is effective for alveolar ridge preservation in fresh extraction sockets with dehiscence defects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12818","type":"journal-article","created":{"date-parts":[[2020,12,12]],"date-time":"2020-12-12T12:59:50Z","timestamp":1607777990000},"page":"298-305","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effects of combined use of recombinant human fibroblast growth factor\u20102 and \u03b2\u2010tricalcium phosphate on ridge preservation in dehiscence bone defects after tooth extraction: A split\u2010mouth study in dogs"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1066-7541","authenticated-orcid":false,"given":"Shunsuke","family":"Fukuba","sequence":"first","affiliation":[{"name":"Department of Periodontology Graduate School of Medical and Dental Sciences Medical and Dental University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Akizuki","sequence":"additional","affiliation":[{"name":"Department of Periodontology Graduate School of Medical and Dental Sciences Medical and Dental University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takanori","family":"Matsuura","sequence":"additional","affiliation":[{"name":"Department of Periodontology Graduate School of Medical and Dental Sciences Medical and Dental University Tokyo 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