{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:25:58Z","timestamp":1791498358894,"version":"4.3.4"},"reference-count":61,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,26]],"date-time":"2020-12-26T00:00:00Z","timestamp":1608940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81441127"],"award-info":[{"award-number":["81441127"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82003546"],"award-info":[{"award-number":["82003546"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and objective<\/jats:title>\n                    <jats:p>Although the association between tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1) G\u2010308A (rs1800629) polymorphism and chronic periodontitis (CP), chronic periodontitis with type 2 diabetes mellitus (DP) is assumed, results of this association have been contradictory. The aim of this study was to assess the relationship between rs1800629 polymorphism and CP\/DP susceptibility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched for studies on PubMed, Web of Science, MEDLINE, Chinese National Infrastructure, and WanFang databases. Study selection was performed using specific inclusion and exclusion criteria and fulfilled the PECO (participant, exposure, comparison, and outcome) format. The relationship between rs1800629 polymorphism and CP\/DP susceptibility was evaluated by the effect summary odds ratio (OR) and 95% confidence intervals (CIs). Allele, dominant, and recessive genetic models were computed to assess the strength of the association.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 25 case\u2010control studies were included in the analysis. In the Asian population, TNF\u2010\u03b1 rs1800629 polymorphism was found to be significantly associated with CP in the overall analyses and for all genetic contrasts, while no significant risks were found among Caucasian populations for all genetic contrasts. The TNF\u2010\u03b1 rs1800629 polymorphism was also associated with increased DP risk in Asians under the fixed\u2010effects model, but not in the recessive comparison.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The meta\u2010analysis suggested that TNF\u2010\u03b1 rs1800629 polymorphism might affect the risk of CP and DP, particularly in individuals of Asian descent.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jre.12820","type":"journal-article","created":{"date-parts":[[2020,12,26]],"date-time":"2020-12-26T07:37:55Z","timestamp":1608968275000},"page":"226-235","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Association between TNF\u2010\u03b1 G\u2010308A (rs1800629) polymorphism and susceptibility to chronic periodontitis and type 2 diabetes mellitus: A meta\u2010analysis"],"prefix":"10.1111","volume":"56","author":[{"given":"Liu\u2010Xia","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Oral Medicine School of Stomatology Wannan Medical College  Wuhu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hospital Infection Management Office Wuhu Hospital of Traditional Chinese Medicine  Wuhu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong\u2010Lin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine School of Stomatology Wannan Medical College  Wuhu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing\u2010Ping","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine School of Stomatology Wannan Medical College  Wuhu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue\u2010Juan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine School of Stomatology Wannan Medical College  Wuhu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue\u2010Long","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics School of Public Health Wannan Medical College  Wuhu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8146-1815","authenticated-orcid":false,"given":"Wei\u2010Wei","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics School of Public Health Wannan Medical College  Wuhu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2019.05.007"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc18-S002"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2017.151"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2019.107843"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31678-6"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31149-3"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0415-5"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12058"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.38"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2015.140520"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-019-0752-2"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2018-000535"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.16.1.329"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00056"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12279"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12612"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/8481735"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2017.10.002"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00374"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2010.02.007"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"issue":"1","key":"e_1_2_9_23_1","first-page":"S11","article-title":"Comment on: American diabetes association. 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