{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T22:26:01Z","timestamp":1789683961293,"version":"4.0.1"},"reference-count":55,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,12]],"date-time":"2020-12-12T00:00:00Z","timestamp":1607731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this systematic review and network meta\u2010analysis was to assess the efficacy of antimicrobials adjunctive to scaling and root planing (SRP) in the treatment of chronic periodontitis. The study was conducted according to the PRISMA statement. The protocol (CRD42020178621) was registered on the International Prospective Register of Systematic Reviews (PROSPERO). The MEDLINE, EMBASE, and CENTRAL databases were searched up to March 2020; furthermore, a manual search of relevant periodontal journals was conducted. Mean differences (MD) and standard deviations were calculated for clinical attachment level (CAL) gain and probing depth (PD) reduction at 6 and 12\u00a0months. A network meta\u2010analysis was performed to assess direct and indirect comparisons and to establish a ranking of treatments. A total of 21 randomized clinical trials (RCTs) were included in the systematic review. Network meta\u2010analysis showed that SRP\u00a0+\u00a0amoxicillin (AMX) + metronidazole (MTZ), as compared to SRP, reached the highest PD reduction at 6 [MD\u00a0=\u00a00.47; 95% CI (0.3; 0.64)] and 12\u00a0months [MD\u00a0=\u00a00.51; 95% CI (0.25; 0.78)], and CAL gain at 6 [MD\u00a0=\u00a00.54; 95% CI (0.27; 0.8)] and 12\u00a0months [MD\u00a0=\u00a00.37; 95% CI (0.05; 0.69)]. Network meta\u2010analysis indicated that AMX\u00a0+\u00a0MTZ adjunctive to SRP provided the best improvement in clinical parameters, followed by SRP\u00a0+\u00a0MTZ.<\/jats:p>","DOI":"10.1111\/jre.12821","type":"journal-article","created":{"date-parts":[[2020,12,12]],"date-time":"2020-12-12T12:49:37Z","timestamp":1607777377000},"page":"236-248","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Adjunctive systemic antimicrobials in the treatment of chronic periodontitis: A systematic review and network meta\u2010analysis"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0527-388X","authenticated-orcid":false,"given":"Fabrizio","family":"Sgolastra","sequence":"first","affiliation":[{"name":"Private Practice  San Benedetto del Tronto Marche Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ambra","family":"Petrucci","sequence":"additional","affiliation":[{"name":"Private Practice  Rieti Lazio Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irma","family":"Ciarrocchi","sequence":"additional","affiliation":[{"name":"Private Practice  Sant'Omero Abruzzo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Masci","sequence":"additional","affiliation":[{"name":"Private Practice  Teramo Abruzzo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Spadaro","sequence":"additional","affiliation":[{"name":"Private Practice  Teramo Abruzzo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2002.280102.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2006.00192.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12201"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2009.00302.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12010"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1990.tb00029.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.2003.8.1.115"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12221"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.110625"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13264"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-015-0123-6"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12427"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2009.01499.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60046-5"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.7326\/M14-2385"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000100"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-151-4-200908180-00135"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(01)00377-8"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0006-341X.2000.00455.x"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-5-13"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.1044"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.3767"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.03.016"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.1045"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyt074"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/0091270010373929"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12721"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12559"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080403"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12004"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.070493"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2012.01870.x"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.01040.x"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.110519"},{"key":"e_1_2_9_38_1","first-page":"137","article-title":"Clinical and microbiological efficacy of systemic roxithromycin as an adjunct to non\u2010surgical periodontal therapy in treatment of chronic periodontitis. A randomized, double\u2010blinded, placebo\u2010controlled clinical trial","volume":"28","author":"Martande SS","year":"2015","journal-title":"Am J Dent"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/jicd.12115"},{"key":"e_1_2_9_40_1","first-page":"e20170075","article-title":"Microbiological and clinical effects of probiotics and antibiotics on nonsurgical treatment of chronic periodontitis: a randomized placebo\u2010 controlled trial with 9\u2010month follow\u2010up","volume":"18","author":"Morales A","year":"2018","journal-title":"J Appl Oral Sci"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01607.x"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.4809695"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2011.03.021"},{"key":"e_1_2_9_44_1","first-page":"67","article-title":"Clinical and microbiological effects of levofloxacin in the treatment of Aggregatibacter actinomycetemcomitans\u2010associated periodontitis: a randomized placebo\u2010controlled clinical trial","volume":"16","author":"Pradeep AR","year":"2014","journal-title":"J Int Acad Periodontol"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/jicd.12091"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.120400"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01766.x"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.4103\/jisp.jisp_254_18"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2001.028004296.x"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-11-159"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13245"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12830"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12089"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12292"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03520290060030"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12946"}],"container-title":["Journal of Periodontal Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jre.12821","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jre.12821","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jre.12821","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T23:50:24Z","timestamp":1693698624000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jre.12821"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,12]]},"references-count":55,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1111\/jre.12821"],"URL":"https:\/\/doi.org\/10.1111\/jre.12821","archive":["Portico"],"relation":{},"ISSN":["0022-3484","1600-0765"],"issn-type":[{"value":"0022-3484","type":"print"},{"value":"1600-0765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,12]]},"assertion":[{"value":"2020-05-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}