{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:13:00Z","timestamp":1787015580310,"version":"build-2736575974"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T00:00:00Z","timestamp":1613606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and objective<\/jats:title>\n                    <jats:p>The application of curcumin is limited by its instability. Mono\u2010carbonyl analogues of curcumin (MCACs) are structurally stable, yet the intermediate bridging ketones in their skeletons account for increased toxicity. This study aimed to synthesize and screen MCACs that exhibit low cytotoxicity and high antioxidant ability, and the effects of MCACs on experimental periodontitis were also investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      The cytotoxicity of MCACs on MC3\u00a0T3\u2010E1 was determined by MTT assay. The antioxidant capacity was investigated by the cell viability against H\n                      <jats:sub>2<\/jats:sub>\n                      O\n                      <jats:sub>2<\/jats:sub>\n                      \u2010induced damage and the level of reactive oxygen species (ROS) and malondialdehyde (MDA). The localization and protein expression of nuclear factor erythroid 2\u2010related factor 2 (Nrf2) and heme oxygenase\u20101 (HO\u20101) was detected by immunofluorescence and western blot, respectively. In addition, MCAC was intragastrically administrated in rats with ligature\u2010induced experimental periodontitis. The effects were assessed by bone resorption, as well as the immunohistology staining of inflammatory and oxidative stress markers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      MCACs with cyclopentanone and containing pyrone showed lower toxicity than natural curcumin were synthesized (\n                      <jats:bold>1A<\/jats:bold>\n                      \u2010\n                      <jats:bold>10A<\/jats:bold>\n                      ,\n                      <jats:bold>1H<\/jats:bold>\n                      \u2010\n                      <jats:bold>10H<\/jats:bold>\n                      ), among which,\n                      <jats:bold>1A<\/jats:bold>\n                      exhibited the most potent cytoprotective effect against H\n                      <jats:sub>2<\/jats:sub>\n                      O\n                      <jats:sub>2<\/jats:sub>\n                      \u2010induced damage. Such effects could be explained by the reduced MDA and ROS level, possibly through the nucleus translocation of Nrf2 and the induction of HO\u20101. Micro\u2010CT results further indicated that\n                      <jats:bold>1A<\/jats:bold>\n                      significantly reduced bone loss, along with an increased level of Nrf2 and HO\u20101, and decreased TNF\u2010\u03b1 and IL\u20101\u03b2.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The present study has synthesized a novel antioxidant MCAC\n                      <jats:bold>1A<\/jats:bold>\n                      with good biosafety and stability. MCAC\n                      <jats:bold>1A<\/jats:bold>\n                      could serve as a host response modulator with preventive and protective effects on periodontitis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jre.12862","type":"journal-article","created":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T17:34:36Z","timestamp":1613842476000},"page":"656-666","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Design, synthesis, and evaluation of mono\u2010carbonyl analogues of curcumin (MCACs) as potential antioxidants against periodontitis"],"prefix":"10.1111","volume":"56","author":[{"given":"Ya","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Periodontics School of Stomatology Wenzhou Medical University Wenzhou 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