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We then examined specimens treated for 1\u00a0week histologically and with immunostaining. Microfocus\u2010computed tomography (micro\u2010CT) was used to examine the bone volume formation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After 1\u00a0week of treatment, proinflammatory cytokine levels (TNF\u2010alpha and IL6), cells exhibiting neutrophil and macrophage marker (MPO), cell proliferation marker (Ki67), and preosteoblastic marker (RUNX2) reactivity decreased in the resveratrol\u2010treated specimens compared to the control group. In contrast, we observed a higher number of CD31\u2010, F4\/80\u2010, and osteocalcin\u2010 (OCN\u2010) positive cells in the resveratrol\u2010treated specimens. After 2\u00a0weeks, micro\u2010CT confirmed an increased bone mass in the region of the extraction socket in the resveratrol\u2010treated group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>After 1\u00a0week, the resveratrol\u2010treated specimens revealed evidence of inflammation modulation compared to the control group. These data suggest that resveratrol not only affects inflammation control but also is useful for treating periodontitis\u2010related tissue defects and bone regeneration.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12870","type":"journal-article","created":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T10:54:46Z","timestamp":1615200886000},"page":"735-745","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Resveratrol enhances bone formation by modulating inflammation in the mouse periodontitis model"],"prefix":"10.1111","volume":"56","author":[{"given":"Nirpesh","family":"Adhikari","sequence":"first","affiliation":[{"name":"Department of Biochemistry School of Dentistry IHBR Kyungpook National University Daegu Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yam","family":"Prasad Aryal","sequence":"additional","affiliation":[{"name":"Department of Biochemistry School of Dentistry IHBR 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