{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T14:41:14Z","timestamp":1792248074511,"version":"4.4.0"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,4,3]],"date-time":"2021-04-03T00:00:00Z","timestamp":1617408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to assess associations between neutrophil\u2010related primary immunodeficiencies (PIDs) and the presence of periodontal disease and other oral diseases and response to periodontal treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Presence of neutrophil\u2010related PIDs is thought to be a major risk factor for development of periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study had both a cross\u2010sectional and cohort design. Twenty\u2010four children (age 4\u201316) with PIDs and 24 age\u2010matched systemically healthy subjects received a dental clinical examination, including measures of probing pocket depths (PPD), clinical attachment loss (CAL) and bleeding on probing (BOP). Those found to be affected by periodontal disease were offered periodontal treatment and reassessed 6\u00a0months later.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Diagnosis of PIDs was associated with increased odds of presence of periodontal disease (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.008 adjusted for age, gender, plaque, OR\u00a0=\u00a010.0, 95% CI\u00a0=\u00a01.83\u201354.38) and with continuous measures of periodontal disease such as number of PPDs &gt;4\u00a0mm, mean PPD and mean CAL (all <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001) and BOP (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.001). However, only 7 out of 24 children were diagnosed with periodontitis. PIDs were also associated with a history of oral ulcers (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.001, OR 12.47, 95% CI 2.71\u201357.29). An improvement in periodontal parameters (PPD and CAL) was detected following oral hygiene instructions and non\u2010surgical periodontal therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although children affected by neutrophil\u2010associated PIDs exhibited a higher prevalence of periodontal disease compared with systemically healthy children, severe periodontitis was rarely seen. This suggests that good systemic control of the PIDs may reduce their impact on the periodontium.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12880","type":"journal-article","created":{"date-parts":[[2021,4,3]],"date-time":"2021-04-03T17:25:15Z","timestamp":1617470715000},"page":"819-827","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Periodontal status in children with primary immunodeficiencies"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7750-5010","authenticated-orcid":false,"given":"Luigi","family":"Nibali","sequence":"first","affiliation":[{"name":"Periodontology Unit Centre for Host Microbiome Interactions Faculty of Dentistry, Oral &amp; Craniofacial Sciences King's College London London UK"},{"name":"Department of Paediatric Dentistry The Royal London Hospital Barts Health NHS Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josephine","family":"Bayliss\u2010Chapman","sequence":"additional","affiliation":[{"name":"Centre for Oral Immunobiology &amp; Regenerative Medicine &amp; Centre for Oral Clinical Research Institute of Dentistry Barts and The London School of Medicine and Dentistry Queen Mary University London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiten","family":"Halai","sequence":"additional","affiliation":[{"name":"Periodontology Unit Centre for Host Microbiome Interactions Faculty of Dentistry, Oral &amp; Craniofacial Sciences King's College London London UK"},{"name":"Centre for Oral Immunobiology &amp; Regenerative Medicine &amp; Centre for Oral Clinical Research Institute of Dentistry Barts and The London School of Medicine and Dentistry Queen Mary University London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl","family":"Somani","sequence":"additional","affiliation":[{"name":"Department of Paediatric Dentistry The Royal London Hospital Barts Health NHS Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Davies","sequence":"additional","affiliation":[{"name":"Centre for Oral Bioengineering Institute of Dentistry Barts and The London School of Medicine and Dentistry Queen Mary University London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Ancliff","sequence":"additional","affiliation":[{"name":"Haematology &amp; Oncology Department Great Ormond Street Hospital for Children London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Donos","sequence":"additional","affiliation":[{"name":"Centre for Oral Immunobiology &amp; Regenerative Medicine &amp; Centre for Oral Clinical Research Institute of Dentistry Barts and The London School of Medicine and Dentistry Queen Mary University London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-007-9103-1"},{"key":"e_1_2_9_3_1","first-page":"16","article-title":"History of primary immunodeficiency diseases in Iran","volume":"20","author":"Aghamohammadi A","year":"2010","journal-title":"Iran J Pediatr"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2009.03.049"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-019-03055-z"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12113"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.1.66"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.17796\/jcpd.34.1.jk4r238521227342"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01784.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1996.67.4.454"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.12968\/denu.2012.39.9.639"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2002.00659.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.17796\/jcpd.29.1.724584t234465907"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.070440"},{"key":"e_1_2_9_15_1","first-page":"105","article-title":"Leukocyte adhesion deficiency: a case report and review","volume":"79","author":"Nagendran J","year":"2012","journal-title":"J Dent Child"},{"key":"e_1_2_9_16_1","first-page":"142","article-title":"Systemic conditions associated with periodontitis in childhood and adolescence. 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