{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:40:23Z","timestamp":1792010423814,"version":"4.4.0"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,9,12]],"date-time":"2021-09-12T00:00:00Z","timestamp":1631404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["380.686\/2013"],"award-info":[{"award-number":["380.686\/2013"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["2.284.225\/2017"],"award-info":[{"award-number":["2.284.225\/2017"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To evaluate how chronic gingivitis treatment impacts the oral and circulating cytokine expressions after six\u2010month follow\u2010up in patients with juvenile systemic lupus erythematosus (jSLE) and also to evaluate the circulating expression of anti\u2010\n                      <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                      peptidylarginine deiminase antibodies (anti\u2010PPAD) before and after treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Juvenile systemic lupus erythematosus patients present a worse periodontal condition associated with higher gingival crevicular fluid (GCF) levels of interleukin (IL)\u20101\u03b2, IL\u20108, granulocyte colony\u2010stimulating factor (G\u2010CSF), interferon\u2010\u03b3 and monocyte chemoattractant protein (MCP)\u20101.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Twenty\u2010one adolescents with jSLE (mean age: 16.2\u00a0\u00b1\u00a01.5\u00a0years) were recruited. Participants were rheumatologically and periodontally examined. All individuals were clinically diagnosed with gingival inflammation. Chronic gingivitis treatment consisted of supragingival scaling, prophylaxis and oral hygiene instructions. The cytokine levels were determined by bead\u2010based multiplex assays and the anti\u2010PPAD levels by ELISA. Gingival crevicular fluid (GCF) and serum samples were collected at baseline and 6\u00a0months after treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We observed a reduction in attachment loss, SLE Disease Activity Index (SLEDAI), IL\u20101\u03b2, IL\u201010 and MCP\u20101 GCF levels, and the IL\u20104 and IL\u20105\u00a0serum levels 6\u00a0months after periodontal treatment. On the contrary, a significant increase in GCF expression of IL\u20104, IL\u201012, IL\u201017, IFN\u2010\u03b3 and serum levels of anti\u2010PPAD antibody was observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Juvenile systemic lupus erythematosus patients seem to positively benefit from periodontal treatment by a significantly reduced CAL, a GCF reduction of pro\u2010inflammatory cytokines and an increasing of anti\u2010inflammatory ones. However, an increase in the GCF expression of IL\u201017 and the serum expression of anti\u2010PPAD antibody 6\u00a0months after periodontal treatment might negatively affect the treatment outcome of such patients in the long term.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jre.12924","type":"journal-article","created":{"date-parts":[[2021,9,12]],"date-time":"2021-09-12T14:33:38Z","timestamp":1631457218000},"page":"1132-1140","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Impact of chronic gingivitis management on the cytokine and anti\u2010PPAD expressions in juvenile systemic lupus erythematosus: A six\u2010month follow\u2010up"],"prefix":"10.1111","volume":"56","author":[{"given":"Manuela Rubim C.","family":"Sete","sequence":"first","affiliation":[{"name":"Department of Periodontology Faculty of Odontology Rio de Janeiro State University  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana C.","family":"Carlos","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Odontology Rio de Janeiro State University  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joao M.","family":"Mello\u2010Neto","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Dentistry Griffith University  Gold Coast QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronaldo","family":"Lira\u2010Junior","sequence":"additional","affiliation":[{"name":"Division of Oral Diagnostics and Rehabilitation Department of Dental Medicine Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda","family":"Brito","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Odontology Rio de Janeiro State University  Rio de Janeiro 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