{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T19:30:19Z","timestamp":1789241419839,"version":"build-2803163510"},"reference-count":59,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,9,19]],"date-time":"2021-09-19T00:00:00Z","timestamp":1632009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study was conducted to evaluate the clinical, immunologic, and patient\u2010centered outcomes of enamel matrix protein derivative (EMD) on excisional wounds in palatal mucosa.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials<\/jats:title>\n                    <jats:p>\n                      Forty\u2010four patients in need of ridge preservation were randomly allocated into two groups: control group (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a022): open palatal wound after free gingival graft (FGG) harvest and EMD group (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a022): open palatal wound after FGG harvest that received 0.3\u00a0ml of EMD. Clinical and patient\u2010centered parameters were analyzed for 3\u00a0months post\u2010treatment. Wound fluid levels of inflammatory markers were assessed 3 and 7\u00a0days postoperatively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      No significant inter\u2010group difference was observed in remaining wound area and re\u2010epithelialization. EMD and control groups achieved wound closure and re\u2010epithelialization 30\u00a0days postoperatively (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.001), without inter\u2010group differences. Similarly, number of analgesics and Oral Health Impact Profile scores did not present significant inter\u2010group differences (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&gt;\u00a0.05). EMD appeared to selectively modulate wound fluid levels of monocyte chemoattractant protein\u20101, macrophage inflammatory protein\u20101\u03b1, matrix metallopeptidase 9, and tissue inhibitor of metalloproteinases\u20102.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Within the limits of the present study, it can be concluded that EMD application to excisional palatal wounds using the investigated protocol does not provide clinical healing benefits, despite an apparent modulation of selected inflammatory markers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jre.12934","type":"journal-article","created":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T02:23:04Z","timestamp":1632104584000},"page":"1213-1222","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Enamel 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