{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T11:09:46Z","timestamp":1785928186261,"version":"3.56.0"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T00:00:00Z","timestamp":1638403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004799","name":"Australian Dental Research Foundation","doi-asserted-by":"publisher","award":["2748\u20102020"],"award-info":[{"award-number":["2748\u20102020"]}],"id":[{"id":"10.13039\/501100004799","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the effect of <jats:italic>Hfe<\/jats:italic> gene mutation on the distribution of iron and periodontal bone loss in periodontal tissues.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background data<\/jats:title><jats:p>It remains unclear how tissue iron loading affects the periodontium architectures in a genetic animal model of hereditary haemochromatosis (HH).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Male C57BL\/6 <jats:italic>Hfe<\/jats:italic>\n<jats:sup>\u2212\/\u2212<\/jats:sup> (8\u00a0weeks old) and wild\u2010type (WT) mice were utilized to examine the iron distribution in periodontal tissues, as well as periodontal tissues changes using micro\u2010computed tomography and histomorphometric analysis. Furthermore, tissue inflammatory mediators, bone markers and periodontal pathogens were carried out in PFA\u2010fixed paraffin\u2010embedded tissues using ELISA, RT\u2010qPCR and genomic DNA qPCR, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Excessive iron deposition was found in the periodontal ligament, gingiva and alveolar bone in <jats:italic>Hfe<\/jats:italic>\n<jats:sup>\u2212\/\u2212<\/jats:sup> mice relative to their WT counterparts. This, in turn, was associated with significant periodontal bone loss, increased cemento\u2010enamel junction\u2010alveolar bone crest distance and decreased expression of molecules involved in bone development and turnover. Furthermore, the pro\u2010inflammatory cytokine \u2010 interleukin 6 and periodontal bacteria \u2013 <jats:italic>Campylobacter rectus<\/jats:italic> were significantly increased in <jats:italic>Hfe<\/jats:italic>\n<jats:sup>\u2212\/\u2212<\/jats:sup> mice compared with WT controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggest that the iron loading in a mouse model of HH decreases alveolar bone formation and leads to alterations in the inflammatory state in the periodontium. Periodontal health should be assessed during the clinical assessment of HFE\u2010HH patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12959","type":"journal-article","created":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T17:37:53Z","timestamp":1638466673000},"page":"294-304","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Iron accumulation is associated with periodontal destruction in a mouse model of HFE\u2010related haemochromatosis"],"prefix":"10.1111","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7546-1635","authenticated-orcid":false,"given":"Pingping","family":"Han","sequence":"first","affiliation":[{"name":"School of Dentistry Centre for Orofacial Regeneration, Reconstruction and Rehabilitation (COR3) Epigenetics Nanodiagnostics and therapeutics Group The University of Queensland  Herston QLD Australia"},{"name":"School of Dentistry The University of Queensland  Herston QLD 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