{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:13:00Z","timestamp":1787015580377,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T00:00:00Z","timestamp":1639526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objective<\/jats:title>\n                    <jats:p>This study aimed to investigate the correlation between chronic periodontitis (CP) and abnormal circular RNA (circRNA) expression and to identify the role of hsa_circ_0003948 in the progression of CP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Next\u2010generation sequencing was utilized to investigate abnormal expression of circRNA in gingival tissues from CP patients and healthy control subjects. Bioinformatics and luciferase reporting analyses were used to clarify the interactive relationship among circRNA, miRNA, and mRNA. Periodontal ligament cells (PDLCs) were employed to analyze proliferation and apoptosis after lipopolysaccharide (LPS) treatment using the cell counting kit 8 (CCK8) assay and flow cytometry detection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>High\u2010throughput sequencing and RT\u2010qPCR analyses confirmed that hsa_circ_0003948 expression decreased dramatically in gingival samples of CP patients. Overexpression of hsa_circ_0003948 alleviated LPS\u2010induced PDLC injury by regulating NR2F2\/PTEN signaling. The miR\u2010144\u20103p and NR2F2 were determined to be hsa_circ_0003948 downstream targets. NR2F2 downregulation or miR\u2010144\u20103p overexpression reversed the protective effect of hsa_circ_0003948 in PDLCs after treatment with LPS. Upregulation of NR2F2 reversed the inhibitory effect of miR\u2010144\u20103p on surviving PDLCs after LPS treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Overexpression of hsa_circ_0003948 exerts a protective effect in CP via miR\u2010144\u20103p\/NR2F2\/PTEN signaling regulation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jre.12961","type":"journal-article","created":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T06:24:21Z","timestamp":1639549461000},"page":"316-323","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Abnormal hsa_circ_0003948 expression affects chronic periodontitis development by regulating miR\u2010144\u20103p\/NR2F2\/PTEN signaling"],"prefix":"10.1111","volume":"57","author":[{"given":"Wei","family":"Li","sequence":"first","affiliation":[{"name":"Department of Stomatology Beijing Chao\u2010Yang Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Stomatology Beijing Fengtai District Nanyuan Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Stomatology Beijing Chao\u2010Yang Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuomin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Stomatology Beijing Chao\u2010Yang Hospital Capital Medical University  Beijing 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