{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T15:51:45Z","timestamp":1790783505999,"version":"4.1.0"},"reference-count":59,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T00:00:00Z","timestamp":1641168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and objectives<\/jats:title><jats:p>This meta\u2010analysis of observational studies (PROSPERO registration number CRD42021236054) sought to investigate strength and generalizability of the association of herpes simplex virus type 1 (HSV\u20101) in subjects with plaque\u2010induced gingivitis and periodontitis, since the data from literature are contrasting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Case\u2013control and cross\u2010sectional studies, investigating HSV\u20101 in subgingival plaque\/crevicular fluid and periodontal status, were searched through MEDLINE via PubMed, Scopus, Web of Science and Google Scholar. From each study the crude odds ratio (OR) with 95% confidence interval (95CI) was extracted, and the pooled OR was assessed for periodontitis, chronic and aggressive, and gingivitis. The meta\u2010analytic method was chosen based on the level of heterogeneity. The generalizability of results, determined by the meta\u2010analysis bias, was investigated through secondary analyses including sensitivity analyses for study quality, publication bias, and study inclusion, and subgroup analyses for quality of scientific journals that published the primary studies, world Region, subgingival plaque sampling method and study design.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twelve studies were included (738 cases, 551 controls). The pooled ORs were 4.4 (95CI, 1.9\u201310.2) for any periodontitis; specifically, 2.8 (95CI, 1.0\u20138.3) for chronic periodontitis, 11.8 (95CI, 5.4\u201325.8) for aggressive periodontitis and 4.8 (95CI, 2.1\u201311.0) for gingivitis. These estimates were statistically significant, excluding for chronic periodontitis, resulting marginally significant (<jats:italic>p\u00a0<\/jats:italic>=\u00a0.05). Secondary analyses on any and aggressive periodontitis, and, partly, chronic periodontitis corroborated the results, while the material was insufficient for secondary analyses on gingivitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results obtained indicated that HSV\u20101 is associated with periodontitis, while data about gingivitis are inconclusive. HSV\u20101 investigation in subgingival plaque could help assess periodontitis risk and severity and, if causal association were confirmed, could contribute to its control.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.12968","type":"journal-article","created":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T08:44:34Z","timestamp":1641199474000},"page":"256-268","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Herpes simplex virus type 1 in subgingival plaque and periodontal diseases. 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