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We included only randomized clinical trials (RCTs) with at least 3\u2010months follow\u2010up of non\u2010surgical periodontal therapy, in combination with dietary omega\u20103 fatty acids. The MEDLINE, EMBASE, and LILACS databases were searched for articles published up to October 2021. Random\u2010effects meta\u2010analyses were conducted to determine the change in clinical attachment level (CAL), probing pocket depth (PPD), bleeding on probing (BOP), and gingival index (GI) after therapy. Of the eight hundred eighty\u2010four potentially relevant papers retrieved from the electronic databases, 10 RCTs were selected for qualitative analysis, and of these, 8 RCTs were included in meta\u2010analysis. RCTs showed a significant PPD reduction\/CAL gain associated with the use of omega\u20103 fatty acids. The pooled estimates revealed significant overall PPD reduction of 0.42\u00a0mm (95% CI 0.15, 0.68) and CAL gain 0.58\u00a0mm (95% CI 0.24, 0.92). In individuals with periodontitis, the use of omega\u20103 fatty acid dietary supplementation as an adjunct to non\u2010surgical periodontal treatment can provide additional benefits in CAL gain and PPD reduction, compared with non\u2010surgical periodontal treatment alone.<\/jats:p>","DOI":"10.1111\/jre.12984","type":"journal-article","created":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T05:34:06Z","timestamp":1646372046000},"page":"435-447","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Does the use of omega\u20103 fatty acids as an adjunct to non\u2010surgical periodontal therapy provide additional benefits in the treatment of periodontitis? 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