{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T21:12:43Z","timestamp":1790975563590,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T00:00:00Z","timestamp":1652745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>While it is well\u2010established that patients that develop signs of relapsing periodontitis in supportive periodontal care (SPC) will need to repeat subgingival instrumentation of the residual pockets, less certainty is available in terms of which protocol should be followed and whether the use of adjunctive therapies or physical agents might provide additional benefits to repeated instrumentation alone. The aim of this systematic review was therefore to assess whether repeating subgingival instrumentation in combination with adjunctive therapies (other than antimicrobials) might provide a significant benefit in terms of pocket closure, probing pocket depth (PPD) reduction or clinical attachment level (CAL) gain in patients during SPC with residual\/relapsing pockets. Four databases were searched to identify randomized controlled trials (RCTs) and controlled clinical trials (CCTs) with a minimum follow\u2010up of 3\u00a0months that investigated the use of adjunctive therapies (other than antimicrobials) in case of residual\/relapsing pockets in patients in SPC since at least 3\u00a0months. Data extraction and risk of bias assessment were performed in the studies meeting the inclusion criteria and meta\u2010analysis was performed when \u22653 studies assessing the same adjunctive therapy were identified. 12 studies (2 CCTs and 10 RCTs) were included for qualitative analysis. Meta\u2010analysis was performed only for 3 studies on the adjunctive use of photodynamic therapy (PDT) and it indicated a nonsignificant benefit compared to the placebo in terms of PPD reduction and CAL gain at 3\u00a0months (weighted mean difference 0.07 and \u22120.03, respectively) and at 6\u00a0months of follow\u2010up (weighted mean difference \u22120.09 and \u22120.18, respectively). While antiseptics did not provide significant benefits, one study on probiotics and one on the use of vitamin D and calcium supplementation showed significant improvements in periodontal parameters. There is currently insufficient\/poor evidence to determine the efficacy of adjunctive strategies (other than antimicrobials) to improve the outcomes of SPC in case of residual\/relapsing pockets.<\/jats:p>","DOI":"10.1111\/jre.13001","type":"journal-article","created":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T10:40:00Z","timestamp":1652784000000},"page":"671-689","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The efficacy of adjunctive periodontal therapies during supportive periodontal care in patients with residual pockets. A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8781-1997","authenticated-orcid":false,"given":"Elena","family":"Calciolari","sequence":"first","affiliation":[{"name":"Centre for Oral Clinical Research, Institute of Dentistry, Barts and The London School of Medicine and Dentistry Queen Mary University of London  London UK"},{"name":"Dental School, Department of Medicine and Surgery University of Parma  Parma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinar","family":"Ercal","sequence":"additional","affiliation":[{"name":"Centre for Oral Clinical Research, Institute of Dentistry, Barts and The London School of Medicine and Dentistry Queen Mary University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Dourou","sequence":"additional","affiliation":[{"name":"Centre for Oral Clinical Research, Institute of Dentistry, Barts and The London School of Medicine and Dentistry Queen Mary University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliye","family":"Akcali","sequence":"additional","affiliation":[{"name":"Centre for Oral Clinical Research, Institute of Dentistry, Barts and The London School of Medicine and Dentistry Queen Mary University of London  London UK"},{"name":"Department of Periodontology, Faculty of Dentistry Dokuz Eylul University  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Tagliaferri","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery University of Parma  Parma Italy"},{"name":"Centre for Research in Toxicology (CERT) University of Parma  Parma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4117-9073","authenticated-orcid":false,"given":"Nikolaos","family":"Donos","sequence":"additional","affiliation":[{"name":"Centre 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