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Some investigations have suggested a dysbiotic association between the oral\u2010gut microbiome and pathogenesis of arthritis and PJIs. A better understanding of the role of the oral\u2010gut microbiota in arthritis and PJI pathophysiology can shed light into how its disequilibrium can discharge a pro\u2010inflammatory response, and impact the health of patients susceptible to arthritis or with established joint disease. A review of published\n                    <jats:italic>in vivo<\/jats:italic>\n                    and clinical data suggested that alterations in oral and gut microbiota can lead to a disturbance of immunoregulatory properties, and may be associated with joint infections and arthritis. This review brings new insights into the current status of the evidence on the potential molecules and inflammatory biomarkers disrupted by an oral\u2010gut microbial dysbiosis. Normal commensals and pathogenic oral and gut microflora homeostasis are important not only to prevent infections\n                    <jats:italic>per se<\/jats:italic>\n                    but also its potential progression. Further experiments, especially controlled clinical trials, are needed to ascertain how microbiome manipulation and other microbiota\u2010directed approaches can help control inflammation and effectively prevent and treat arthritic diseases. Additionally, studies on the effects of the long\u2010term oral diseases, such as chronic periodontitis, on arthritis and PJIs need to be conducted.\n                  <\/jats:p>","DOI":"10.1111\/jre.13002","type":"journal-article","created":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T07:43:44Z","timestamp":1652859824000},"page":"711-723","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Dysbiotic relationship between arthritis and the oral\u2010gut microbiome. 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