{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T13:57:25Z","timestamp":1782482245761,"version":"3.54.5"},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T00:00:00Z","timestamp":1654646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003042","name":"Else Kr\u00f6ner-Fresenius-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003042","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Previous epidemiological studies regarding the association between chronic periodontitis (CP) and carotid intima\u2010media thickness (cIMT) and subclinical atherosclerosis have been inconclusive.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to determine whether CP is associated with subclinical atherosclerosis in a large population\u2010based cohort study conducted in northern Germany (the Hamburg City Health study).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Baseline data from 5781 participants of the Hamburg City Health Study with complete oral health and carotid ultrasound data (50.7% female, mean age: 62.1\u00a0\u00b1\u20098.4\u2009years) were evaluated. A standardized duplex sonography of the carotid artery was performed with measurement of carotid intima\u2010media thickness (cIMT) and atherosclerotic plaques. Oral health was assessed by recording the decayed, missing, and filled teeth (DMFT) index, clinical attachment loss (CAL), bleeding on probing (BOP), and the dental plaque index (PI). Correlations were tested for statistical significance by means of descriptive statistics and multivariate regression analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Moderate and severe CP were associated with the prevalence of cIMT\u2009\u2265\u20091\u2009mm (none or mild CP: 5.1%, moderate CP: 6.1%, severe CP: 10%) and mean cIMT (none or mild CP: 0.72\u2009mm, moderate CP: 0.75\u2009mm, severe CP: 0.78\u2009mm) in bivariate analyses (<jats:italic>p<\/jats:italic>\u00a0&lt;\u2009.001). Additionally, severe and moderate CP were associated with higher prevalence of carotid atherosclerotic plaques (plaque\u00a0=\u00a0yes: none or mild CP: 23.9%, moderate CP: 29%, severe CP: 40.2%,). After adjustment for age, sex, smoking, diabetes, hypertension, educational level, hypercholesterolemia, and hsCRP, severe CP still correlated significantly with cIMT and the prevalence of cIMT \u22651\u2009mm and\/or presence of carotid atherosclerotic plaques.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this study, severe CP was associated with increased cIMT and higher prevalence of carotid plaques independent of common risk factors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.13021","type":"journal-article","created":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T15:16:27Z","timestamp":1654701387000},"page":"824-834","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Cross\u2010sectional analysis of the association of periodontitis with carotid intima media thickness and atherosclerotic plaque in the Hamburg City health study"],"prefix":"10.1111","volume":"57","author":[{"given":"Ragna","family":"Lamprecht","sequence":"first","affiliation":[{"name":"Department of Prosthetic Dentistry, Center for Dental and Oral Medicine University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Leander","family":"Rimmele","sequence":"additional","affiliation":[{"name":"Department of Neurology University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renate B.","family":"Schnabel","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Heart and Vascular Center  Hamburg Germany"},{"name":"German Center for Cardiovascular Research (DZHK) Partner Site Hamburg\/L\u00fcbeck\/Kiel  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Heydecke","sequence":"additional","affiliation":[{"name":"Department of 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