{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T10:55:18Z","timestamp":1791888918123,"version":"4.3.4"},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,6,4]],"date-time":"2022-06-04T00:00:00Z","timestamp":1654300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004202","name":"Ondokuz Mayis \u00dcniversitesi","doi-asserted-by":"publisher","award":["1901.16.003"],"award-info":[{"award-number":["1901.16.003"]}],"id":[{"id":"10.13039\/501100004202","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective and Background<\/jats:title><jats:p>Both periodontitis and osteoporosis are associated with osteoclast\u2010related bone resorption. Bone metabolism is regulated by wingless\u2010type MMTV integration site family (WNT), and WNT\/\u03b2\u2010catenin signals are controlled by physiological antagonists including dickkopf\u20101 (DKK\u20101) and sclerostin (SOST). This study examined the effects of periodontal and bisphosphonate (BP) treatment on the gingival crevicular fluid (GCF) sclerostin (SOST) and dickkopf\u2010related protein\u20101 (DKK\u20101) levels in osteoporotic and systemically healthy postmenopausal women with and without periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A total of 48 postmenopausal women were divided into 4 groups (<jats:italic>n<\/jats:italic>\u00a0=\u00a012) according to periodontal health and osteoporosis status, as follows: Group OP\/P: subjects with both osteoporosis and periodontitis; Group P: systemically healthy subjects with periodontitis; Group OP: periodontally healthy subjects with osteoporosis; Group H: systemically and periodontally healthy controls. Clinical data and GCF SOST and DKK\u20101 levels of the participants were collected at baseline and at 6 and 12\u2009months following the initiation of periodontal and\/or BP treatment in the experimental groups. GCF SOST and DKK\u20101 data were obtained by ELISA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Clinical improvements were observed in all experimental groups. GCF SOST and DKK1 baseline levels varied significantly between groups due to periodontal disease (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Following treatment, significant increases in SOST and DKK\u20101 concentrations and significant decreases in total amounts of SOST were observed in both periodontitis groups (OP\/P, P). However, while total amounts of DKK\u20101 decreased in Group OP\/P, in Group P, these amounts had significantly increased at 12\u2009months post\u2010treatment (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). At both 6 and 12\u2009months post\u2010treatment, SOST and DDK1 total amounts in Groups OP\/P, OP, and H were similar (<jats:italic>p<\/jats:italic>\u2009&gt;\u2009.05), whereas significant differences were observed between Groups H and P, indicating a deviation from periodontal health in Group P (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Significant changes in GCF SOST and DKK\u20101 levels were observed among women with osteoporosis who received both periodontal and BP treatment. A more detailed examination of how these treatment protocols can be combined may lead to new therapeutic approaches towards periodontal disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.13023","type":"journal-article","created":{"date-parts":[[2022,6,4]],"date-time":"2022-06-04T10:14:20Z","timestamp":1654337660000},"page":"849-858","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Effects of periodontal and bisphosphonate treatment on the gingival crevicular levels of sclerostin and dickkopf\u20101 in postmenopausal osteoporosis with and without periodontitis"],"prefix":"10.1111","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3258-3979","authenticated-orcid":false,"given":"Feyza Otan","family":"Ozden","sequence":"first","affiliation":[{"name":"Department of Periodontology, Faculty of Dentistry Ondokuz May\u0131s University  Samsun 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