{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T15:13:34Z","timestamp":1768490014388,"version":"3.49.0"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T00:00:00Z","timestamp":1660694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Chronic periodontitis is caused by multiple risk factors. To predict chronic periodontitis in older people, we evaluated the association between a combination of major periodontal pathogens and salivary biomarkers and the presence of periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Stimulated saliva samples were collected to analyze the prevalence of <jats:italic>Porphyromonas gingivalis<\/jats:italic>, <jats:italic>Treponema denticola<\/jats:italic>, <jats:italic>Tannerella forsythia<\/jats:italic>, and <jats:italic>Prevotella intermedia<\/jats:italic>, as well as four biomarkers: interleukin (IL)\u20101\u03b2, IL\u20106, tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1), and prostaglandin E2 (PGE2). A total of 201 Japanese patients were recruited. Oral examinations ware performed to determine chronic periodontitis as measured by Community Periodontal Index. The sociodemographic and behavioral characteristics were also obtained, and the parameters were adjusted as potential confounders to employ statistical models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The odds ratio (OR) for the presence of <jats:italic>P.\u00a0gingivalis<\/jats:italic> and the third tertile level of IL\u20101\u03b2 as compared with the absence of <jats:italic>P.\u00a0gingivalis<\/jats:italic> and the lowest tertile of IL\u20101\u03b2 was highest in individuals with periodontitis (OR\u00a0=\u00a013.98; 95% confidence interval [CI] 3.87\u201350.52) with the best level (0.79) of area under the curve (AUC) based on the receiver operating characteristic curve. The OR for the presence of <jats:italic>P.\u00a0gingivalis<\/jats:italic> and the third tertile of PGE2 was 7.76 (CI 1.89\u201331.91) with an AUC of 0.78. The coexistence of more than two periodontal bacteria and the third tertile of PGE2 was also strongly associated with chronic periodontitis (OR\u00a0=\u00a09.23, 95% CI 2.38\u201335.79) with an AUC of 0.76.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The combined information of the presence of <jats:italic>P.\u00a0gingivalis<\/jats:italic> in stimulated saliva, and higher levels of salivary IL\u20101\u03b2 may play a vital role in the detection and prediction of chronic periodontitis in older adults.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.13048","type":"journal-article","created":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T05:15:49Z","timestamp":1660799749000},"page":"1083-1092","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Validity of a combination of periodontal pathogens and salivary biomarkers as predictors of periodontitis"],"prefix":"10.1111","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3097-088X","authenticated-orcid":false,"given":"Hyeonjeong","family":"Go","sequence":"first","affiliation":[{"name":"Department of Preventive Dentistry School of Dentistry Kyungpook National University  Daegu Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3288-8887","authenticated-orcid":false,"given":"Taejun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Preventive Dentistry School of Dentistry Kyungpook National University  Daegu Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9298-2296","authenticated-orcid":false,"given":"Ah\u2010Ra","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Preventive Dentistry School of Dentistry Kyungpook National University  Daegu Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3773-8976","authenticated-orcid":false,"given":"Yun\u2010Sook","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Dental Hygiene Kyungpook National University  Sangju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5158-147X","authenticated-orcid":false,"given":"Atsuo","family":"Amano","sequence":"additional","affiliation":[{"name":"Department of Preventive Dentistry Osaka University Graduate School of Dentistry  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5416-5500","authenticated-orcid":false,"given":"Keun\u2010Bae","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Preventive Dentistry School of Dentistry Kyungpook National University  Daegu Korea"},{"name":"Facial nerve\u2010Bone Network Research Center Kyungpook National University  Daegu Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5712-8097","authenticated-orcid":false,"given":"Youn\u2010Hee","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Preventive Dentistry School of Dentistry Kyungpook National University  Daegu Korea"},{"name":"Institute for Translational Research in Dentistry Kyungpook National University  Daegu Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,17]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"WHO Oral Health Country\/Area Profile Programme WCC Malmo University Sweden.Periodontal Country Profiles An overview of CPITN data in the WHO Grobal Oral Data Bank.https:\/\/www5.dent.niigatau.ac.jp\/~prevent\/perio\/contents.html. 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