{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T19:44:00Z","timestamp":1781379840344,"version":"3.54.1"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T00:00:00Z","timestamp":1665964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004799","name":"Australian Dental Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004799","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study investigated the impact of colitis induced by dextran sulphate sodium (DSS)\u2010induced colitis (DIC) on histopathological and immunological outcomes in the periodontal tissues of Wistar rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Inflammatory bowel diseases (IBD) and periodontitis have been reported to present a bidirectional relationship. However, the inflammatory pathway that connects both diseases needs further investigation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Twenty\u2010five male Wistar rats were allocated in four groups: unilateral ligature\u2010induced periodontitis for 14\u2009days: LIP (<jats:italic>n<\/jats:italic>\u00a0=\u00a07); dextran sulphate sodium\u2010induced colitis only: DIC (<jats:italic>n<\/jats:italic>\u00a0=\u00a06); DIC\u2009+\u2009LIP (<jats:italic>n<\/jats:italic>\u00a0=\u00a06) and controls (<jats:italic>n<\/jats:italic>\u00a0=\u00a06). Digital images were obtained from the histological sections. In order to assess the attachment loss (AL), the linear distance between the cementoenamel junction (CEJ) and the alveolar bone crest was measured on the mesial root using histological photomicrography's ImageJ software. Immunological analyses of gingival tissues and plasma were performed by Bio\u2010Plex Th1\/Th2 Assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The DIC group showed inflammatory cells extending to the periodontal connective tissues, which contained significantly elevated expressions of IL\u20101\u03b1, IL\u20101\u03b2, IL\u20102, IL\u20106, IL\u201012, IL\u201013, GM\u2010CSF, IFN\u2010\u03b3 and TNF\u2010\u03b1 compared to controls. There was no significant difference in bone loss between controls and DIC. There were no significant histopathological differences between DIC\u2009+\u2009LIP and LIP. However, DIC\u2009+\u2009LIP presented a significantly lower IL\u20102 and IL\u20105 than the LIP group. There was no bone loss difference between LIP+DIC and LIP groups. DIC\u2009+\u2009LIP group presented significantly higher levels of GM\u2010CSF in plasma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>DSS\u2010induced colitis was associated with an overexpression of Th1\/Th2\u2010 related cytokines in the gingival tissue.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.13063","type":"journal-article","created":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T03:59:50Z","timestamp":1666065590000},"page":"1267-1276","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Colitis induced by dextran sulphate sodium causes histopathological and immunological changes in the periodontal tissues of Wistar rats"],"prefix":"10.1111","volume":"57","author":[{"given":"Jo\u00e3o Martins","family":"de Mello\u2010Neto","sequence":"first","affiliation":[{"name":"School of Medicine and Dentistry Griffith University  Southport Queensland 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