{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:04:06Z","timestamp":1790633046367,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T00:00:00Z","timestamp":1670803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>Soluble ST2 (sST2) is a current biomarker of cardiovascular disease. It is used to predict susceptibility to cardiovascular diseases and to analyze their prognosis. Serum sST2 level increases in inflammatory diseases such as periodontitis. However, the level of sST2 in peri\u2010implant diseases and crevicular fluid has not been investigated yet. Thus, the aim of this cross\u2010sectional study is to analyze the level of sST2 in peri\u2010implant health and diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty\u2010nine participants were divided into 3 groups as peri\u2010implant health (PH), peri\u2010implant mucositis (PM), and peri\u2010implantitis (P\u2010I). Peri\u2010implant crevicular fluid (PICF) and serum samples were collected from each participant. The levels of sST2 and IL\u20106 in PICF and sST2, IL\u20106, and CRP in serum were compared between the groups. Pocket depth (PD), modified bleeding index (mBI), modified plaque index (mPI), keratinized mucosa index (KTW), and gingival\/mucosal recession (REC) were recorded as clinical parameters. Biomarkers in the serum and PICF were analyzed by ELISA kit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010nine patients were included in the study. The differences in the following parameters were statistically significant between groups: age (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.009), implant function time (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.027), PD (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), mBI (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), mPI (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), and KTW (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.043). The PICF volume of P\u2010I and PM groups were statistically higher than PH (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). The amount of sST2 in P\u2010I and PM groups were higher than PH (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.043). Serum CRP was higher in the P\u2010I group than in other groups (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.034). There were no significant differences in serum sST2 (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.247) and IL\u20106 (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.110) levels between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The PICF levels of sST2 were significantly higher in PM and P\u2010I groups compared to the healthy group. However, no significant difference was observed between the groups in terms of serum sST2 level.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.13082","type":"journal-article","created":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T11:08:17Z","timestamp":1670843297000},"page":"204-211","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Peri\u2010implant crevicular fluid and serum levels of soluble <scp>ST2<\/scp> in peri\u2010implant diseases: A pilot study"],"prefix":"10.1111","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7911-198X","authenticated-orcid":false,"given":"Engin","family":"Ozgur","sequence":"first","affiliation":[{"name":"Department of Periodontology, Faculty of Dentistry Ba\u015fkent University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1219-6368","authenticated-orcid":false,"given":"Deniz 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