{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:39:18Z","timestamp":1791200358363,"version":"4.2.0"},"reference-count":63,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T00:00:00Z","timestamp":1672099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Periodontitis is a highly prevalent disease in psychiatric patients, including those undergoing symptomatic treatment with second\u2010generation antipsychotics. Some of these drugs, such as clozapine (CLO) and olanzapine (OLA), have prominent metabolic effects such as weight gain, hyperglycemia, and dyslipidemia, which are risk factors for periodontitis. In addition to the metabolic effects, there are reports of changes in salivary flow, gingival bleeding, and caries. In this context, we aimed to evaluate if the metabolic effects of OLA and CLO alter periodontal parameters in an animal model of periodontitis without the environmental and psychosocial biases inherent to human diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In the first set of experiments, male and female adult Wistar rats received oral administration of CLO, OLA, or vehicle for 45\u2009days. They were evaluated for body mass composition and weight gain, blood glucose parameters (fasting and glucose tolerance and insulin resistance tests), and lipid profile (HDL, total cholesterol, and triglycerides). In a second set of experiments, the same measurements were performed in female rats exposed to the antipsychotics for 45\u2009days and ligature\u2010induced periodontitis on the 30th day of treatment. Macroscopic measurements of exposed roots, microtomography in the furcation region of the first molar, and histological evaluation of the region between the first and second molars were evaluated to assess bone loss. Additionally, gingival measurements of myeloperoxidase activity and pro\u2010inflammatory cytokine TNF\u2010\u03b1 were made.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Only females exposed to OLA had more significant weight gain than controls. They also exhibited differences in glucose metabolism. Ligature\u2010induced periodontitis produced intense bone retraction without changing the density of the remaining structures. The bone loss was even higher in rats with periodontitis treated with OLA or CLO and was accompanied by a local increase in TNF\u2010\u03b1 caused by CLO. These animals, however, did not exhibit the same metabolic impairments observed for animals without periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The use of clozapine and olanzapine may be a risk factor for periodontal disease, independent of systemic metabolic alterations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.13090","type":"journal-article","created":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T04:11:27Z","timestamp":1672200687000},"page":"283-295","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Atypical antipsychotics olanzapine and clozapine increase bone loss in female rats with experimental periodontitis"],"prefix":"10.1111","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3279-6050","authenticated-orcid":false,"given":"Mariana Alves","family":"Soares","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Estudos em Farmacologia Experimental (LEFEx), Departamento de Biotecnologia Farmac\u00eautica, Faculdade de Farm\u00e1cia Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil"},{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Farmacologia e Qu\u00edmica Medicinal, Instituto de Ci\u00eancias Biom\u00e9dicas Universidade Federal do Rio de Janeiro, Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2170-7940","authenticated-orcid":false,"given":"Andr\u00e9 Luiz A.","family":"Costa","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Estudos em Farmacologia Experimental (LEFEx), Departamento de Biotecnologia Farmac\u00eautica, Faculdade de Farm\u00e1cia Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2749-5336","authenticated-orcid":false,"given":"Nat\u00e1lia L. 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