{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T18:24:14Z","timestamp":1749147854099,"version":"3.40.5"},"reference-count":51,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T00:00:00Z","timestamp":1678838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005646","name":"Actelion Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005646","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Periodontal disease occurs frequently in patients with limited cutaneous systemic sclerosis (lcSSc) while data about underlying pathways contributing to periodontal changes are scarce. The aim of this study was to evaluate periodontal disease and to investigate its association with endothelial dysfunction and clinical changes in patients with lcSSc.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 38 lcSSc patients and 38 controls, periodontal status was evaluated by disease\u2010specific questionnaire, dental examination including bleeding on probing (BOP), pocket depth, and plaque index, and dental panoramic radiograph. Periodontopathogen bacteria were collected subgingivally using paper points and interleukin\u20101 (IL\u20101) gene polymorphisms were evaluated using buccal swabs. Endothelial dysfunction was measured by flow\u2010mediated dilatation, pulse\u2010wave velocity and biochemical analysis, including arginine metabolites and endothelial microparticles. Additionally, lcSSc\u2010specific clinical changes and parameters were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Periodontitis was present in 31 patients with lcSSc (81.6%) and in 27 controls (71.1%) (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.280). LcSSc patients had a lower teeth number (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.039) and <jats:italic>Eikenella corrodens<\/jats:italic> was to a higher degree detectable in patients with lcSSc (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.041) while the remaining periodontal parameters revealed no differences between both cohorts. Significant correlations between parameters of arterial stiffness, EUSTAR index, number of teeth and BOP were observed (all <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). Detection of <jats:italic>Prevotella intermedia<\/jats:italic> was associated with selected IL\u20101 gene polymorphisms (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.032) and <jats:italic>Porphyromonas gingivalis<\/jats:italic> was associated with severe periodontitis (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.041).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Periodontal disease may occur frequently in patients with lcSSc and may be associated with arterial stiffness and with SSc activity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.13111","type":"journal-article","created":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T09:53:11Z","timestamp":1678873991000},"page":"621-633","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Periodontal disease and its association to endothelial dysfunction and clinical changes in limited systemic sclerosis: A\u00a0case\u2013control study"],"prefix":"10.1111","volume":"58","author":[{"given":"Philipp","family":"Jud","sequence":"first","affiliation":[{"name":"Division of Angiology, Department of Internal Medicine Medical University of Graz  Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gernot","family":"Wimmer","sequence":"additional","affiliation":[{"name":"Division of Restorative Dentistry, Endodontics, Periodontology and Prosthodontics, Department of Dental Medicine and Oral Health Medical University of Graz  Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Meinitzer","sequence":"additional","affiliation":[{"name":"Clinical Institute of Medical and Chemical laboratory diagnostics Medical University of Graz  Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heimo","family":"Strohmaier","sequence":"additional","affiliation":[{"name":"Department center of medical research Medical University of Graz  Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3349-1101","authenticated-orcid":false,"given":"Gerold","family":"Schwantzer","sequence":"additional","affiliation":[{"name":"Institute for Medical Informatics, Statistics and Documentation Medical University of Graz  Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florentine","family":"Moazedi\u2010F\u00fcrst","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine Medical University of Graz  Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leyla","family":"Schweiger","sequence":"additional","affiliation":[{"name":"Division of Angiology, Department of Internal Medicine Medical University of Graz  Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne","family":"Brodmann","sequence":"additional","affiliation":[{"name":"Division of Angiology, Department of Internal Medicine Medical University of Graz  Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franz","family":"Hafner","sequence":"additional","affiliation":[{"name":"Division of Angiology, Department of Internal Medicine Medical University of Graz  Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5685-3796","authenticated-orcid":false,"given":"Behrouz","family":"Arefnia","sequence":"additional","affiliation":[{"name":"Division of Restorative Dentistry, Endodontics, Periodontology and Prosthodontics, Department of Dental Medicine and Oral Health Medical University of Graz  Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,3,15]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30933-9"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38098"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2007.12.004"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh671"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kel426"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1309\/LM9OB5BZ4OSNVGVF"},{"issue":"9","key":"e_1_2_11_8_1","first-page":"831","article-title":"Small mouths \u2026 big problems? 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