{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T13:12:58Z","timestamp":1790341978443,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T00:00:00Z","timestamp":1678924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the association between the prevalence of cyclosporin A\u2010induced gingival overgrowth and the expression of the epithelial\u2010to\u2010mesenchymal transition factors in the gingival tissues of renal transplant patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Gingival overgrowth (GO) is a frequent complication in organ transplant patients treated with the immunosuppressant cyclosporin A (CsA). The epithelial\u2010to\u2010mesenchymal transition (EMT) is considered a factor contributing to CsA\u2010induced GO. However, current knowledge on this topic is sparse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty\u2010three renal transplant patients were divided into two groups according to the occurrence of GO: those with gingival overgrowth (GO+ group) and those without gingival overgrowth (GO\u2212 group). Data on age, sex, and use of immunosuppressant and calcium channel blocker medications, serum creatinine values, peak concentrations of blood CsA, and gingival hyperplasia scores were recorded to identify clinically pathogenic factors. Gingival tissues from five patients with CsA\u2010induced GO and five healthy subjects were selected for histomorphological observation with hematoxylin\u2013eosin staining, Masson staining, and immunohistochemical staining. The mRNA expression of EMT factors was detected with reverse transcription\u2013quantitative PCR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The use of CsA significantly increased the prevalence of GO in renal transplant patients. The expression of \u03b1\u2010SMA, SMAD4, and TGM2 was upregulated and that of E\u2010cadherin was downregulated in the gingival tissues of patients with CsA\u2010induced GO compared with those of the corresponding controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Treatment with CsA is closely related to the occurrence of GO in renal transplant patients and EMT plays an important role in CsA\u2010induced gingival tissue hyperplasia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jre.13115","type":"journal-article","created":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T07:53:55Z","timestamp":1678953235000},"page":"511-519","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cyclosporine A\u2010induced gingival overgrowth in renal transplant patients accompanied by epithelial\u2010to\u2010mesenchymal transition"],"prefix":"10.1111","volume":"58","author":[{"given":"Min Zhi","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Stomatology, Zhongshan Hospital Fudan University  Shanghai China"},{"name":"Shanghai Jing\u2010An Dental Clinic  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao Feng","family":"Dai","sequence":"additional","affiliation":[{"name":"Shanghai Jing\u2010An Dental Clinic  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Zhongshan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You Cheng","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Zhongshan Hospital Fudan University  Shanghai China"},{"name":"Department of Stomatology, Xiamen Branch, Zhongshan Hospital Fudan University  Xiamen 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